A Review of 58 Rh‐Isoimmunised Cases

Abstract

Rh-isoimmunised patients over a period of four years are analysed. The incidence of iso-immunisation is 3.3%. 5.7% cases were immunized inspite of receiving post-partum Anti-D immunoglobulin, and 2.8% cases were immunised in their first pregnancy. Spectrophotometry is invaluable, while antibody titres predict perinatal outcome reliably in the first affected pregnancy. The perinatal mortality of the registered cases is 15.5%. 46.1% o f the total perinatal deaths were due to premature still births which can be prevented only by mastering the technique of intrauterine transfusion.

Frequency of Antibodies in Haemolytic Disease of Foetus and Newborn

“…35 Prevalence of Rh-D alloimmunisation from different centres had a wide range from 0.8% to 4.0% and one study conducted in the same setting reported a frequency of 3.12%. 41,42,43,44 While independent 't' test was performed between ABO and Rh-D HDFN assemblies there was no significant difference regarding maternal age, duration of treatment and duration of stay in ICU. Regarding cord blood haemoglobin and bilirubin levels, there was significant difference in mean values in ABO and Rh-D HDFN cases.…”