Plasma levels of 14 amino acids were determined in 44 probands with 3/sec spike-wave epilepsy, 27 of their first-degree relatives, and 22 controls. Six ratios of metabolically related amino acids were also calculated. Statistically significant differences were found for 7/20 variables when the experimental and control probands were compared, and for 6/20 variables when the relatives were compared with controls. Tau, Asp, and Tau/Glu were decreased and Glu was was increased in both the experimental probands and their first degree relatives. When discriminant analysis was used, age- and sex-matched epileptic probands could be distinguished from the age- and sex-matched control probands with 100% accuracy employing only 3 amino acids (Asp, Glu, Val) and one ratio (Thr/Ser).
In the present study a typical plasma amino acid profile for a defined population of healthy Venezuelan children was established and, further, the possibility was examined that deviations from such normalized amino acid patterns can be of use to warn of an impending nutritional deficiency, caused, in part, by adverse socio-economic conditions. This study comprised 152 children of both sexes ranging in age from 1 to 6 years. Classification into different socio-economic strata, ranging from impoverished to privileged, was evaluated by Graffar's method, as previously adapted by Mendez Castellano for Venezuela. The results of clinical and anthropometric examinations were used to group these children into 5 classes of nutritional sufficiency, ranging from adequate nutrition to severe undemutrition. The present data indicate that deviations in the plasma amino acid concentration profile, standardized for a defined population, can be used in combination with clinical evaluations to determine the type as well as the severity of inadequate nutrition. Abnormal ratios of several individual amino acids relative to Val and Tau may serve as early signs of (impending) undemutrition or malnutrition in children; the amino acid changes are detectable even in groups of children without any clinical signs but where sociological circumstances suggest a possibility of inadequate nutrition. Other uses for such plasma amino acid profiles may be to distinguish whether the detected amino acid abnormalities are of dietary or genetic origin, provided that the selected groups or individuals studied derive from a population with more or less the same genetic homogeneity and similar dietary customs.
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