Two naturally occurring homoisoflavonoids (3h,3i) and nine analogs (2a-2i) have been synthesised from appropriately substituted phenols thorough 1-(2-hydroxyphenyl)-3-phenylpropane-1-ones (1a-1i). The anti-oxidant and anti-fungal activities were determined by superoxide (NBT) and Agar cup method respectively. The reaction of 1-(2-hydroxyphenyl)-3-phenylpropane-1-ones with triethylorthoformate and 70% perchloric acid followed by aqueous hydrolysis of the intermediate perchlorates, the corresponding homoisoflavones (2a-2i) are obtained in excellent yields. Thereafter, 2a-2i has been converted into homoisoflavanones by subjecting to catalytic hydrogenation. This methodology has been applied for the first time for the synthesis of (±)-dihydrobonducellin (3h) and (±)-2 ' -methoxydihydrobonducellin (3i), which have been isolated from Caesalpinia pulcherrima.
Ketoximes and aldoximes are expeditiously prepared by the reaction of the corresponding carbonyl compound with hydroxylamine hydrochloride in dimethylformamide, in the presence of a sub-stoichiometric quantity of glycine at room temperature. Mild (non-hydroxylic) conditions, simple workup and high yield characterise the methodology.
A Simple and Effective Glycine-Catalyzed Procedure for the Preparation of Oximes. -Mild conditions and simple work-up characterize the title methodology. -(MAHESWARA, M.; SIDDAIAH, V.; GOPALAIAH, K.; RAO, V. M.; RAO*, C.
N-Tosyl-α-aminonitriles have been synthesised by a Strecker reaction of various N-tosyl aldimines with trimethylsilyl cyanide in the presence of catalytic amount of Amberlyst-15 polymer at room temperature under heterogeneous conditions.
Amberlyst-15 Catalyzed Synthesis of N-Tosyl-α-aminonitriles Through StreckerReaction. -A simple and efficient method for the formation of the title compounds (III) from N-tosyl aldimines and Tms-SCN using Amberlyst-15 as catalyst is described. Mild reaction conditions, short reaction time and excellent yields are the most important advantages of the reported procedure. -(SUDHAKAR, D.; RAO, V. M.; SURESH, M.; RAO*, C. V.; J.
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