Background and objectives: Certain clinical conditions are related to the presence of platelet-specific alloantibodies in the patient’s serum. We studied the molecular diversity of HPA-1a antibodies to analyze some peculiarities of this antibody response. Materials and methods: Human antibody Fab fragments that bind to the platelet alloantigen HPA-la on glycoprotein Ilb-IIIa (GPIIbllla) were generated by using a recombinant phage display system. We established an immunoglobulin Gl, kappa combinatorial library from the peripheral blood lymphocytes of a person undergoing a severe posttransfusion purpura. Results: Characterization of Fab clones selected from the fifth round of antigen-specific panning of this library demonstrates a highly specific reactivity to the HPA-1a alloantigen. The nucleotide sequence analysis of representative HPA-1a-specific clones reveals at least 3 distinct VL and 3 V(H) gene segments that present an extensive degree of mutation as demonstrated by comparison of gene usage and homologies to the nearest germline genes. Conclusions: These human HPA-laspecific Fab reagents should allow us to better understand the molecular mechanism involved in HPA-1a alloimmunization.

We describe the Auto and Autograph tools for verification and analysis of concurrent systems in their more recent developments. Auto is dedicated to a philosophy of verification by reduction, based on automata morphisms and quotients. Autograph provides a graphical layout on which to display both terms and informations on terms, back and forth to Auto. We stress the openness aspects of both systems and their interface formats to the outside world. We see this as a contribution to the ever growing collaborative trends between similar tools, mostly under the pressure of national or European Esprit projects.

This study aims to identify which therapeutic factors supported members in their commitment to a group for abusive men. Seventy-one members of therapy groups for men who batter were asked to rank therapeutic factors based on how they experienced the relative importance of these factors in their experience at the beginning of the group process. Findings indicate that at this stage, abusive men place greater importance on cognitive aspects that correspond to a process of self-understanding and awareness of their problem, whereas the interactive and emotional aspects of the group experience appear less significant. Results are discussed in terms of members’ characteristics and purposes for these groups.

This article examines the findings of an ecological analysis of the factors influencing men's engagement in intimate partner violence (IPV) groups. Individual interviews and two focus groups were conducted with men who participated in group programs in two agencies in Canada. Our qualitative analysis of interviews and focus groups suggested that both individual and program-related factors were determinants in the men's engagement. These findings drew our attention to the influence of certain factors outside of the group therapy, in particular organizational practices. Implications for practice are explored, in particular the role of time in the intervention, and implications for research and limitations are discussed.

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HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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La violence conjugale est un problème social grave et persistant ; le tiers des femmes de la planète en a déjà été victime. Cet article vise à discuter des liens empiriques et théoriques entre les violences conjugales, familiales et structurelles. L’article débutera par une brève mise en contexte décrivant comment la violence conjugale s’est construite comme un problème socio-pénal au Québec. Les principales lacunes des connaissances actuelles dans le domaine seront ensuite identifiées, démontrant ainsi la nécessité de mieux comprendre les liens complexes entre les violences conjugales, familiales et structurelles, trois concepts dont les définitions pourraient s’enrichir et se compléter mutuellement. Cet article soulignera l’importance de prendre en considération les réalités diversifiées auxquelles sont confrontés les acteurs concernés par ces violences (femmes, hommes et enfants), en privilégiant une analyse globale qui intègre non seulement les facteurs individuels et interpersonnels, mais aussi les facteurs sociaux et structurels, notamment les oppressions liées au genre ou à d’autres marqueurs de l’identité sociale. La discussion sera enrichie par des modèles théoriques décrivant les différentes dynamiques de violences conjugales et familiales ainsi que par le féminisme intersectionnel, qui s’avère fort utile pour l’analyse des violences structurelles. La conclusion traitera des retombées potentielles d’une analyse des liens entre les violences conjugales, familiales et structurelles sur les politiques sociales et les programmes d’intervention pour les victimes, les agresseurs et les enfants exposés à la violence conjugale.