this paper presents the results of a study and modeling of the influence of the solvent's dielectric constant on the extraction of eugenol from the Laurus nobilis L leaves. The aim of this work is to study the effect of the solvent on the extraction of eugenol from the leaves of Laurus nobilis L., to propose a theoretical model for describing the results. Shredded plant material of Laurus nobilis L. leaves 0.1-0.5 mm. Aqueous solutions of ethanol (23, 39, 55, 73, 80, 96±1% v/v). The extracts were obtained by a ratio of plant materialsextractant 1:5 (w/v), insisting for 24 hours at a temperature of 24±1°C. Analysis of the extracts was carried out using reverse phase high performance liquid chromatography and a standard sample of eugenol. The dependence of the concentration of eugenol in alcohol-water extracts on the concentration of ethanol in solution was studied. It was found that the maximum concentration of eugenol is observed in solutions with ethanol concentrations of 85±15 % vol. This range of ethanol concentrations corresponds to a dielectric constant of the solvent of 33.5±3.5 units. The regression equation of the dependence of the concentration of eugenol in the extract on the dielectric constant of alcohol-water solutions is obtained. It was found that the dielectric constant of the solvent has the most significant effect on the process of isolating the phytocomponent from plant materials. A mathematical model is theoretically grounded and tested to describe the dependence of the concentration of eugenol on the dielectric constant of water-ethanol solutions. The optimal range of solvent dielectric constant was found to achieve the maximum concentration of eugenol in the extract.
The article provides an overview of modern data on the main gel bases used in the technology of semisolid dosage forms. The main classes of gelling substances are characterized. According to data, the choice of excipient must be justified from the point of view of the physicochemical properties of the active substance, and depends on the place of application of the gel.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.