Intermetallic (Cu-Sn) nanoparticles are synthesized through a borohydride reduction with NaBH4 in a mixture of aqueous solutions of CuCl2.2H2O and SnCl2.2H2O at mass ratio Cu:Sn = 3:2 applying a template technique with a support such as carbon foam. The ratio is chosen in accordance with the Cu-Sn binary system phase diagram. The reductive precipitation is carried out at room temperature and atmospheric pressure. Porous nanocomposites are obtained and studied by scanning and transmission electron microscopy (SEM/TEM), and X-ray diffraction (XRD) analysis. The electrochemical behavior of the synthesized Cu-Sn alloy and the C-based composites (С-foam/Cu-Sn alloy) as positive electrodes is also investigated in a Li-ion battery) using a computer controlled laboratory cycling equipment BA500 Series Battery Analyzer.
Intermetallic (Co-Sn, Ni-Sn, Co-Ni) nanoparticles have been synthesized through a borohydride reduction with NaBH4 in aqueous solutions of the chloride salts of Co, Ni, Sn at room temperature using a template technique with a carbon support. As a result nanocomposite materials have been obtained in situ. The ratio of the metallic components has been chosen according the phase diagrams of the relevant binary (Co-Sn, Ni-Sn, Co-Ni) systems: Co:Sn=35:65, Ni:Sn=45:55, Co:Ni=50:50. As carbon supports have been used graphite and carbon powder. To avoid the nanoparticle’s aggregation b-cyclodextrin has been added to the reaction solutions. To study the influence of the supports used on the morphology, specific surface area, elemental and phase composition of the synthesized intermetallic nanoparticles and their carbon nanocomposites SEM, EDS, BET, and XRD investigation techniques have been used. The particle’s morphology varies with the different supports, but in the all cases it is typical for alloyed materials. The nanoparticles are different in shape and size and exhibit a tendency to aggregate. The last-one is due to the unsaturated nanoparticle’s surface and the existing magnetic forces. Regardless of the elemental composition, the nanosized particles are characterized by a relatively high specific surface area (SSA). The Ni-Sn nanoparticle have the largest SSA (80 m2/g), while the Co-Sn particles have the lowest SSA (69 m2/g). The use of a carrier modifies the SSA of the resulting nanocomposites differently depending on the size and shape of the carrier’s particles. The studies conducted on the intermetallic nanoparticles synthesized with various carriers demonstrate that the particle’s morphology, size, and specific surface area for the different supports are suitable for use as catalysts, electrode materials in Li-ion batteries and as magnetic materials for biomedical applications.
performed spatial transcriptomic profiling to elucidate the molecular differences between TZ and PZ PCa.METHODS: We identified three patients who underwent radical prostatectomy for PCa (one each with PZ only, TZ only, and both PZ and TZ tumors) and used the NanoString's Digital Spatial Profiling (DSP) platform to quantify whole transcriptomic gene expression data (17,128 genes) in multiple regions of interest (ROI) per patient (42 cancer and 8 normal samples). Four morphology markers to facilitate ROI selection in both cancer and normal areas (SYTO13 for nucleus, PanCK for epithelium, SMA for stroma and CD45 for immune cells) were selected. Raw counts for 17,128 genes were imported to R v.4.1.0 for downstream data analyses. Counts were Q3 normalized and scaled (Z-score) to enable plotting of all genes on the same axes. Differential gene expression analysis using a linear model fit by empirical Bayes moderation, gene set enrichment analysis (GSEA) by cancer hallmarks, XCell gene sets for pathway enrichment and immune cell deconvolution using CIBERSORT was performed.RESULTS: There were grade group (GG) 4 (n[10) and 5 (n [10) tumors in PZ and GG 3 (n[10), 4 (n[11) and 5 (n[1) cancers in TZ regions. We observed distinct gene expression profiles between PZ (n [ 20) and TZ (n[22) tumors. Interestingly, androgen receptor (AR) signaling was significantly higher in TZ PCa ROIs compared to PZ ROIs in both GSEA (false discovery rate < 5%) and the androgen subcomponent of the genomic prostate score (p<0.001), regardless of grade, epithelial, stromal or immune component of the region. To standardize the comparison, CIBERSORT's absolute immune signature scores were only computed for GG4 tumors and found to be significantly higher in PZ GG4 tumors compared to TZ GG4 tumors. Notably, CD4þ memory T cells were significantly higher in PZ GG4 regions compared to TZ GG4 tumor regions (p<0.05).CONCLUSIONS: Here, we demonstrate distinct gene expression profiles of PZ and TZ PCa. Specifically, we observed higher AR signaling in TZ cancers and higher levels of immune infiltration on PZ cancers. This is in concordance with prior knowledge that TZ tumors may be associated with higher serum PSA and PZ tumors may be associated with inflammation. Further studies are needed to discern the biological and clinical significance of the different molecular features of PZ and TZ PCa.
The phase diagram of the (Sb 2 Te 3 ) 1002x -InSb x system was determined based on x-ray diffraction (XRD) analysis, differential thermal analysis (DTA), and microhardness and density measurements. An intermediate compound with composition Sb 2 Te 3 AE2InSb was formed as a result of syntectic reaction, melting incongruently at 553°C. This compound has tetragonal lattice with unit cell parameters of a = 4.3937 Å , b = 4.2035 Å , c = 3.5433 Å , a = 93.354°, and b = c = 90°. Sb 2 Te 3 AE(2 + d)InSb (21 £ d £ +1) and (Sb 2 Te 3 ) 1002x (InSb) x (90 £ x £ 100) solid solutions exist in the investigated system, based on the intermediate compound Sb 2 Te 3 AE2InSb and on InSb, respectively. Also, two invariant equilibria exist in the system, with eutectic point coordinates at compositions of x = 60 and x % 85 mol% InSb and eutectic temperatures of T E = 541 and T E 501°C, respectively.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.