Genetic susceptibility or resistance to diseases is currently drawing increasing attention. This work describes two different breeding herds showing signs of periweaning failure-to-thrive syndrome (PFTS), an emergent swine disease. The disease was diagnosed based on clinical picture and confirmed by histopathology. The possibility of main infectious pathogens was ruled out by immunohistochemistry and PCR. In a simple approach, sires of the affected piglets have been determined using microsatellite paternity analysis, including a healthy group in each case. In each of the two farms, a single boar was found to have sired 45-50 per cent sick animals. Removal of this sire from two farms resulted in a significant decrease in the prevalence of the disease among the offspring, in accordance with other two cases diagnosed, although without including a control group. Since the analysed animals belonged to three different genetic lines, these findings point to the existence of individual genetic susceptibility to this syndrome.
Introduction: Atypical odontalgia (AO) is one of the most complicated challenges that a dentist can face for an adequate diagnosis and treatment plan. It can cause prolonged visits and costly overtreatments for the patient, increasing the time of resolution of the condition. Objective: To analyze the literature about AO, as well as its epidemiology, pathophysiology, predisposing factors, associated pathologies and treatment. Methodology: Information was searched in PubMed, SCOPUS and Google Scholar. Key words were used to search for information such as: atypical odontology, epidemiology, pathophysiology, related disease, treatment, among other relevant articles. Results: AO occurs in women (85%) and men (20%) between 50 -60 years old, hormonal or psychiatric disorders, related to local neuropathies due to problems in electrical conduction, and present or largely confused with trigeminal neuralgia and burning mouth syndrome mainly, sometimes it is possible to identify duct treatment or a history of aggressive therapy in the area, and can be treated with Amitriptyline, Imipramine, Aripiprazole, and locally with Botulinum Toxin A with favorable results found at 4 weeks. Conclusion: AO does not have specific characteristic criteria for its diagnosis, leaving a wide spectrum of possibilities that represent a complex pathology that needs further study.
Introduction: Syphilis is a systemic infection of sexual, blood transfusion or transplacental transmission caused by the spirochete Treponema pallidum. Objective: To analyze the literature on the epidemiology, diagnostic methods, clinical and oral manifestations and treatment of Treponema pallidum. Methodology: A literature review was carried out in the PubMed database with the words "Treponema pallidum", together with "epidemiology", "diagnosis", "clinical manifestations", "oral manifestations" and "treatment". Results: It is estimated that each year there are 12 million new cases of syphilis worldwide and more than 90% are from developing countries. Direct detection and serological tests are the available options for identification. Infectious ulceration is the sign of primary disease, while secondary disease is characterized by multisystem involvement. Late syphilis involves neurosyphilis, cardiovascular syphilis and gummatous syphilis, which may coexist. The oral manifestation presents as one or more ulcers depending on the stage. The main treatment for syphilis is penicillin, although its effectiveness will depend on the stage of the disease. Conclusions: Due to its increasing incidence, it is of great relevance that the dentist is familiar with the clinical appearance, especially oral, of this pathology for early diagnosis and treatment.
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