The present study was aimed at determining the effects of medicinal herbs adjuvants on growth, hematoebiochemical parameters, some non-specific immunity and disease resistance to Photobacterium damselae in Sobaity sea bream (Sparidentex hasta). The fish (mean body weight 3.08±0.31 g) were fed fishmeal diets supplemented with either 1% of Garlic (Allium sativum), 1% supplemented of Ginger (Zingiber officinale), 1% supplemented of thyme (Thymus vulgaris), a mixture of these herbs (1% Garlic + 1% Ginger + 1% thyme), and control diet without medicinal herbs, for 8 weeks. The highest weight gains (WG %) and the specific growth rate (SGR) were in fish that fed diets with the mixture of three medicinal herbs (P<0.05). The number of WBC and RBC showed a significant increase in ginger and the mixture of three medicinal herbs compared to the control (P<0.05). The highest total protein and the lowest cholesterol levels were observed in treated groups with ginger diet (P<0.05). The highest albumin and the lowest triglyceride levels were achieved in mixture of these three herbsgroup. The analysis of AST and ALT were significantly decreased in the mixture of these three herbs and ginger groups (P<0.05). The lowest ALP level were showed in mixture of these three herbs group. Furthermore, serum lysozyme activity, total immunoglobulin (Ig) and complement activity (ACH50) were significantly increased in the mixture of three medicinal herbs fed fish and ginger groups (P<0.05). After feeding experiment, fish were infected with Photobacterium damselae strain FN1 and mortalities were recorded. The results of this study demonstrated that dietary mixture of three medicinal herbs and ginger groups could be an improvement in the growth and some non-specific immunity of Sobaity sea bream fry.