a b s t r a c tBackground: Nowadays multiple primary tumor is characterized by growth and development of two or more tumors in one patient. The total world sickness rate ranges from 1% to 37%. The presence of four or more tumors in one patient is rare case and presented as casuistry. Case presentation: We showed a case of multiple primary tumor with metahronic lesion of the thyroid, uterus and breast, followed by synchronous benign tumors of the subcutaneous fat, urinary bladder and gallbladder were considered. The development of all malignant tumors in all cases was accompanied by the presence of benign precancerous processes. Analysis of neoplasia histology shows the predominance of poorly differentiated forms of cancers in women with increased aggressiveness of cancerous tissue in each subsequent case and the growth of metastatic ability. The influence of heredity on the tumors progress is confirmed by immunohistochemical characteristics of cancer cells. Steroid-sensitive tissue of the uterus and breast in both cases didn't express ER and PR, in all cases the tissue had overexpression of Ki-67, p53, bax and bcl-2 receptors. The results of DNA testing for determination the Lynch syndrome revealed the presence of microsatellite instability in genetic material. The results of studies revealed the absence of mutations in these genes (MLH1, MSH2 and MSH6). Despite the negative results of the study, it doesn't exclude the possibility of Lynch syndrome for 100%, and its presence may be caused by the mutations of other genes (PMS1, PMS2 and MLH3), responsible for DNA repair. Unfortunately there wasn't any opportunity to study their mutations. Conclusions: While studying the anamnesis of life and disease of women it was revealed that she had multiple primary tumor with lesions of the breast, urinary bladder, thyroid, uterus and other organs. This study shows that neoplastic tissue in all cases had high rates of cell proliferation, their antiapoptotic stability, expression of prognostically unfavorable-receptors, and absence of favorable prognostic markers. Histological study revealed high rates of malignant neoplastic tissue. It indicates to the existence of common mechanisms of malignant tumors and their genetic predisposition that can be clearly observed in many generations of patient.

The article investigates the concept of the healthy development of regions as a purposeful process of development of all spheres of life of a territorial unit. Its authors consider it an essential component of the successful development of a country in a market economy. The situation of the regions is a macroeconomic indicator. In today's market conditions, the sustainable development of the regions is hindered by such a crisis-forming factor as the COVID-19 pandemic. Ensuring effective counteraction to its negative impact is a determinant of forming the strategic potential of the country. The authors consider the coronavirus pandemic as a factor that initially affected the health care system and, in a relatively short period, spread to various areas of the socio-economic situation of entire countries and regions. The study performed a bibliometric analysis of the fundamental concepts of "economic crisis" and "pandemic" in their relationship. The authors analyze the main approaches to the isolation of economic cycles related to the turning points in the history of society, in particular, the crisis phenomena that force the world to adapt, change and modernize various spheres of life. They highlight the initial parameters of the market position of some countries in the European region that involved in the fight against the consequences of the spread of COVID-19. Most countries are adversely affected by the spread of coronavirus, which affects macroeconomic policies' effectiveness and the subsequent strategy for managing essential quality of life parameters. They give forecasts of opportunities to overcome the crisis in their economies. They conclude that the scale of the impact of the coronavirus pandemic on the country depends on the measures of its government to counter local opportunities to review economic regimes. The authors construct the map of the economic impact of COVID-19 at different levels with isolated crisis events on each analyzed wave of the spread of the consequences of the crisis-forming factor. Many of the effects of a pandemic can be seen in the short term, while others are diagnosed in the medium and long term.

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The authors of the article consider the COVID-19 pandemic as a factor that has hurt various world economy sectors. Events caused by restrictive actions by governments in quarantine measures to reduce the spread of coronavirus have worsened the financial and economic situation of several businesses on a regional scale. The situation in the world's economy highlights the need for comprehensive research in forecasting and leveling the harmful effects of epidemics of this scale at different levels of the socio-economic sphere of individual regions. The study aims to summarize the material on the spread of the COVID-19 pandemic and measures to combat it in different countries for use in the development of tools to prevent such negative phenomena on the economy of individual regions. The authors did a comparative analysis of the state of the critical parameters of government action to reduce the negative impact of COVID-19 in the countries leading the rate of spread of this virus. This ranking includes Ukraine, which is in the top twenty countries with the highest number of detected cases. The impact on the processing industry as the sector most affected by the pandemic is significant for the domestic economy, as this industry is one of those that form the largest share of the country's GDP. The article also presents the results of the research of business respondents in the manufacturing sector. If some of them did not experience significant changes in their work, most small and medium-sized companies suffered losses and suspended their production or reduced their scale. The main problems were the transportation of workers to production facilities, problems with product sales, and additional costs associated with countering the pandemic. The authors made conclusions on the most appropriate tools to support Ukraine's processing industry to overcome the challenges posed by a global pandemic. Key words: COVID-19 pandemic, economic health of a region, economic activity, processing industry, forecast of the socio-economic situation.