The pathogenesis of traumatic spinal cord disease involves two mechanisms causing injury to its neuronal apparatus: primary (necrosis) and secondary (apoptosis). This study assesses the involvement of a number of endogenous factors in the development of apoptosis in spinal cord and peripheral nerve trunk trauma; the role of these factors thus far remains unclear.Keywords: spinal cord and peripheral nerve trunk trauma, pathogenetic mechanisms of apoptosis.
Objective. To analyze the 50 most cited articles related to the diagnosis, classification and surgical treatment of injuries of the thoracolumbar junction, which influenced the study of this problem. Material and Methods. The Web of Science database was searched for keywords to detect articles related to thoracolumbar junction surgery. Articles were selected taking into account the title, abstract and the used methods, and then evaluated by the total number of citations to identify the fifty most cited. Characteristics of publications were analyzed. Results. The United States of America, Thomas Jefferson University and A.R. Vaccaro were the most productive country, institution and author, respectively, dealing with the subject. The 2000s was the most active decade in terms of the number of publications. The greatest attention of scientists dealing with the problems of thoracolumbar injury was attracted by the article by McLain et al. analyzing the causes of the failures of short-segment transpedicular systems in the early postoperative period. The article by Laursen et al. presenting the results of using recombinant bone morphogenetic protein-7 in combination with metal fixation is at the top of the list in terms of average citation index. Most articles are well-designed randomized studies with the evidence level II. Conclusion. Citation analysis allowed to identify the most relevant articles, the authors of which have made a significant contribution to the problem of surgery of the thoracolumbar junction. Study of the information field through the prism of the most cited articles allows seeing the mainstream and future development of diagnostics, classification and treatment of the injuries of this localization.
Objectives. To study some peculiarities of psychophysiology of children and adolescents with scoliosis and to assess its dynamics after surgical treatment. Material and Methods. Total of 58 patients with scoliosis of grade III–IV at the age of 10 to16 years were examined, out of them 17 were operated on by Cotrel – Dubousset technique. Control group consisted of 18 practically healthy individuals of similar age. Clinical, rontgenologic and psychophysiologic methods of analysis were used. Psychoemotional state was assessed by depression level, indexes of personal and reactive anxiety, and by patients’ attitude to their disease and vital functions. Psychovegetative reactivity was evaluated by oculocardiac, cardiac-sinus and celiac-plexus reflexes. The patients were examined three times: before operation, in six and twelve months after operation. Results. Psychophysiologic status of children and adolescents with scoliosis essentially differs from that of normal ones. Psychoemotional disorders are characterized by a high level of depression, situational and personal anxiety, and by violation of social adaptation, and psychovegetative disorders – by increase in lability and reduction of reactivity of the vegetative nervous system. Conclusion. It was revealed that the psychophysiologic status of children and adolescents with scoliosis has essential peculiarities. In the nearest postoperative period the positive dynamics is mainly seen in psychoemotional status, but psychovegetative state remain without any essential dynamics.
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