A series of new 1-(2-arylvinyl)-2-azolyl-1-pyridylethanols-1 has been obtained with various positions of the nitrogen atom in the pyridine fragment and with substituents in the benzene ring, by the reaction of (2-arylvinyloxiran-2-yl)pyridines with triazole and imidazole, for agrochemical screening. The compounds mentioned displayed high fungicidal activity.
A group of fungicidal antibiotics, b-methoxyacrylic acid derivatives (strobilurins, oudemansins, and myxothiazols), their producers, and mechanisms of action are considered. The fungicidal activity of these compounds is based on the suppression of cell respiration of fungi in the bc 1 -complex of cytochromes. They also manifest other biological activities that are not always coupled with inhibition of respiration. Studies of the structure of the natural methoxyacrylates has made it possible to create a novel class of synthetic agricultural fungicides with enhanced stability, high activity, and a broad spectrum of action. The main regularities of the structure ± activity relationship and methods of synthesis of these compounds are discussed. The bibliography includes 159 references.
Esters and N-methylamides of 2-hydroxyimino-and 2-alkoxyimino-3-(acylhydrazono)-butanoic acids were synthesized by condensation of acyl hydrazines with the corresponding alkyl 2-hydroxyimino-and 2-alkoxyimino-3-oxobutanoates and N-methyl-2-methoxyimino-3-oxobutanamide. The compounds obtained are analogs of strobilurins, fungicidal antibiotics 9Key words: esters and amides of 2-hydroxyimino-3-oxobutanoic and 2-alkoxyimino-3-oxobutanoic acids, hydrazones; strobilurin analogs.Strobilurin A (1) is an antibiotic of high fungicidal activity. But it is light-sensitive, which significantly limits the area of its application. 1 There have been synthesized a large number of structural analogs ofstrobilurin A that have various biological activities and are more stable and promising as agrochemical preparations against a broad spectrum of plant diseases. Esters and amides of aryl-and hetarylacetic acids bearing the methoxymethylene or methoxyimino group in the a-position are the major strobilurin analogs studied. 2-4Acylhydrazones of esters and amides of 2-alkoxymethylene-and 2-alkoxyimino-3-oxobutanoic acids (2) are structurally close to strobilurin and therefore can also exhibit similar biological activity.
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