Derivatives of 3-aroyl-2-(methylthio)pyridine are valuable starting materials for obtaining condensed nitrogen-containing heterosystems. In spite of the significant number of studies devoted to the synthesis of these compounds [1-7] their further conversions have not been studied. This is probably explained both by the nonselectivity of the reactions obtaining them [1-3] and the difficulty of availability of the initial reactants [4][5][6][7].
C-1,3-Dinucleophiles. -A series of novel tri-and tetracyclic heterocycles is prepared starting from the key intermediate (IV). The cyclocondensations proceed regioselectively. The anomalous value of the H-7 proton chemical shift in the NMR spectrum of compound (XII), caused by steric hindrance of the phenyl ring in 5-position, is discussed. -(BRITSUN, V. N.; ESIPENKO, A. N.; PIROGHENKO, V. V.; LOZINSKII, M. O.; Chem. Heterocycl. Compd. (N. Y.) 44 (2008) 8, 979-984; Inst. Org. Chem., Natl. Acad. Sci. Ukr., Kiev 02160, Ukraine; Eng.) -H. Haber 23-164
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