ChemInform Abstract: Cyclocondensation of 5‐Benzoyl‐3‐ethoxycarbonyl‐6‐methylthio‐1‐R‐1,2‐dihydropyrid‐2‐ones with Heterocyclic N,N‐ and N,C‐1,3‐Dinucleophiles.

Abstract

C-1,3-Dinucleophiles. -A series of novel tri-and tetracyclic heterocycles is prepared starting from the key intermediate (IV). The cyclocondensations proceed regioselectively. The anomalous value of the H-7 proton chemical shift in the NMR spectrum of compound (XII), caused by steric hindrance of the phenyl ring in 5-position, is discussed. -(BRITSUN, V. N.; ESIPENKO, A. N.; PIROGHENKO, V. V.; LOZINSKII, M. O.; Chem. Heterocycl. Compd. (N. Y.) 44 (2008) 8, 979-984; Inst. Org. Chem., Natl. Acad. Sci. Ukr., Kiev 02160, Ukraine; Eng.) -H. Haber 23-164