This study is aimed at identifying organs and/or target organs systems that are most sensitive to the toxic effect of the drug under study, as well as determining the level of cumulation and reversibility of pathological changes in the animal body influenced by the pharmacological substance. During a 14-day sub-acute (intramuscular injection) experiment on outbred rats, it has been found that doses of 2.260 mg/kg (1/5 of LD50=1.1300 mg/kg) and 1130 mg/kg (1/10 of LD50=1.1300 mg/kg) were toxic and the dose of 565 mg/ kg was threshold (1/20 of LD50=1.1300 mg/kg). The investigated product Florfenicol VS 30 (developed by VETSFERA, Russia) in the tested doses caused a significant decrease in the body weight and significant changes in hematological and biochemical blood parameters. Integral indices in test groups were characterized by severe depression, decreased food activity, weakened skeletal muscle tone, and poor skin turgor. Gastrointestinal disorders were observed during all weight recording periods, while animals were injected with toxic doses. By day 14 of the experiment, the drug at a dose of 565 mg/kg (tolerable level) caused no changes in the behavior of experimental rats or their functional states. The disturbed hemopoiesis and significant hypoproteinemia revealed were reversible.
2 Журавлёва М.С., кандидат ветеринарных наук 1 Абрамов С.В., кандидат ветеринарных наук 2 Головин В.В., главный специалист 2 Кутукова А.Л., ведущий специалист 3 Анисимова Е.Ю., кандидат биологических наук 2 Zhuravleva M.S., candidate of veterinary sciences 1 Abramov S.V., candidate of veterinary sciences 2 Golovin V.V., main specialist 2 Kutukova A.L., leading specialist 3 Anisimova E.Yu., candidate of biological sciences 1 Всероссийский научно-исследовательский институт фундаментальной и прикладной паразитологии животных и растений-филиал ФГБНУ «Федеральный научный центр-Всероссийский научно-исследовательский институт экспериментальной ветеринарии имени К.И. Скрябина и Я.Р. Коваленко РАН», Москва 2 Международный научно-исследовательский центр охраны здоровья человека, животных и окружающей среды, Москва 3 Поволжский научно-исследовательский институт производства и переработки мясомолочной продукции, Волгоград
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