The aim of this study was to determine difference in sexual dysfunction between 137 stabilized male outpatients who met ICD-10 criteria for acute and transient psychotic disorders (F 23) and schizophrenia (F 20) under therapy atypical and typical antipsychotic.Arizona Sexual Experience Scale (ASEX) and the subscale on sexual function of the UKU Side Effects Rating Scale were applied at a single interview.Sexual dysfunction was observed in 55, 47% (76 patients). We find higher ASEX and UKU score in patient with schizophrenia under therapy atypical and typical antipsychotic (p=0, 01). in patients with schizophrenia under typical antipsychotic, orgastic dysfunction (p< 0, 05) is more common.Ejaculatory dysfunction and erectile dysfunction are also high in that group (p< 0, 05).Therapies with atypical and typical antipsychotic have the same effects on increased or diminished sexual desire in bout group of patients.In patients with schizophrenia under typical antipsychotic there is higher ASEX score then in patients under atypical antipsychotic (p< 0, 05). Patients with acute and transient psychotic disorders do not have difference on level of sexual dysfunction in correlation with treated by atypical and typical antipsychotic.Results show that sexual dysfunction is more common in patients with schizophrenia under therapy with typical antipsychotic. in group of patients with acute and transient psychotic disorders there is no difference betven therapy atypical or typical antipsychotic in sexual dysfunction.
To date, 7 of the HRPs developed an affective disorder. These findings suggest that a REM sleep dysregnlation not overt under basal conditions may be demasked by cRIT. In an ongoing study we examine REM sleep dysregnlation with the cRIT in healthy subjects with respect to the HLA-DR2-system and other biological indicators related to affective disorders, i.e. responsitivity of the HPA axis, and the psychometric profile of the subjects.
Posters, Monday, 6 May 2002 records. Details of appeals were obtained from the Court of Appeal patients in the ICM group appeared to assault more during followand a literature search. The reasons for successful appeals were up (p=O.O3) was possibly explained by increased reporting of scrutinised, including the role of Forensic Psychiatry. violent incidents due to these patients spending longer in hospital. Conclusion: ICM cost more for violent patients but was without demonstrable benefits in clinical and social outcomes. Results: Last year 57 automatic life sentences were imposed. Eleven appeals were identified. Four were successful, as defendants were not thought to pose a serious enough risk to warrant indefinite incarceration. Psychiatric risk assessments were used in the decision making. P20.09 Conclusion: The legislation is a blunt instrument which risks imposing life sentences on individuals who do not pose a serious risk to the public. Forensic Psychiatry is providing courts with guidance on risk assessments and assisting case law development.
This was an eight months prospective study.Study was active controlled in patients who were hospitalized in our Clinic. Schizophrenia was diagnosed by using PANSS scale and by using MKB 10 criteria. Laboratory data were measured at baseline, every month after therapy and at endpoint. Laboratory tests included glucose level in serum and OGTT, which were determined from blood, before breakfast and in the same hospital laboratory. Patients with family history of diabetes mellitus were excluded from the study.A total of 30 patients were recruited. the risperidone shows clinically insignificant effect on plasma glucose levels. Incidence of new onset diabetes was abaut 5% higher with olanzapine than risperidone, and the biggest increasing was in first three months. Elevated serum glucose levels have been shown with clozapine and dose-related effects were noted. We also found modest, but significant risk for increasing plasma glucose levels in patients with chlorpromazine medication. Lack of relationship between serum levels of zuclopentixol and plasma glucose has been shown. There are no apparent problems with sulpiride and with haloperidol. Medication with chlorpromazine did not show any significant modifications to blood glucose levels.The antipsychotics appear to be associated with the development of glucose intolerance, new-onset diabetes mellitus and exacerbation of existing diabetes mellitus. These disturbances in glucose metabolism have their own medical consequences. Thus, to minimize morbidity and mortality associated with the use of antipsychotic medications, close screening and monitoring for diabetes mellitus should become a priority for all clinicians treating schizophrenia patients receiving antipsychotic therapy.
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