Rheumatoid arthritis (RA) is a systemic, chronic inflammatory and auto immune disorder. RA is provoked by genetical predisposition and environmental factors. Oxidative stress makes the human liable to diseases like diabetes, RA, cancer, atherosclerosis etc. Hence the study investigated the anti-arthritic and oxidative activity of ethanolic extract of Glycosmis pentaphylla (EEGP) as it has not been pharmacologically tested. Anti-arthritic potential was evaluated in vitro using protein denaturation by bovine serum albumin and in vivo by Complete Freund Adjuvant (CFA) models at 200 and 400mg/kg doses. Also, in vitro and in vivo antioxidant ability was appraised by DPPH scavenging and assessment of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and lipid peroxidation (LPO). The results exhibited concentration dependent inhibition of albumin denaturation with maximum results obtained at 800μg/ml. The results of CFA model depicted better protection against arthritic lesions and body weight alterations. Also G. pentaphylla remarkably ameliorated histopathological changes. Additionally, plant exhibited remarkable anti-oxidant activity.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.