Malaria, a tropical disease caused by Plasmodium sp., has been haunting mankind for ages. Unsuccessful attempts to develop a vaccine, the emergence of resistance against the existing drugs and the increasing mortality rate all call for immediate strategies to treat it. Intense attempts are underway to develop potent analogues of the current antimalarials, as well as a search for novel drug targets in the parasite. The indispensability of apicoplast (plastid) to the survival of the parasite has attracted a lot of attention in the recent past. The present review describes the origin and the essentiality of this relict organelle to the parasite. We also show that among the apicoplast specific pathways, the fatty acid biosynthesis system is an attractive target, because its inhibition decimates the parasite swiftly unlike the 'delayed death' phenotype exhibited by the inhibition of the other apicoplast processes. As the enzymes of the fatty acid biosynthesis system are present as discrete entities, unlike those of the host, they are amenable to inhibition without impairing the operation of the host-specific pathway. The present review describes the role of these enzymes, the status of their molecular characterization and the current advancements in the area of developing inhibitors against each of the enzymes of the pathway.
Safety plays a major role in today's world and it is necessary that good safety systems are to be implemented in places of education and work. This work modifies the existing safety model installed in industries and this system also be used in homes and offices. The main objective of the work is designing microcontroller based toxic gas detecting and alerting system. The hazardous gases like LPG and propane were sensed and displayed each and every second in the LCD display. If these gases exceed the normal level then an alarm is generated immediately and also an alert message (SMS) is sent to the authorized person through the GSM. The advantage of this automated detection and alerting system over the manual method is that it offers quick response time and accurate detection of an emergency and in turn leading faster diffusion of the critical situation.
PurposeOpen tibia fracture is prone to infection, consequently causing significant morbidity and increasing the hospital stay, occupational loss and onset of chronic osteomyelitis. Intramedullary nailing is one choice for treating tibia shaft fractures. To improve the delivery of antibiotics at the tissue-implant interface, many methods have been proposed as a part of prophylaxis against infection. This study was conducted to study the role of gentamicin-impregnated intramedullary interlocking (IMIL) nail in the prevention of infection in Gustilo type I and II open tibia fractures and to compare the results with regular intramedullary nail.MethodsThe study included 28 patients with open tibia fractures (Gustilo type 1 or type 2); of them 14 underwent regular IMIL nailing and the other 14 were treated with gentamicin-coated nailing. Randomization was done by alternate allocation of the patients. Follow-up was done postoperatively (day 1), 1 week, 6 weeks, and 6 months for bone union, erythrocyte sedimentation rate (ESR), hemoglobin and C-reactive protein (CRP). Statistical significance was tested using unpaired t-test. A p value less than 0.05 was considered significant.ResultsThere were 4 cases of infection in controls (regular IMIL nail) and no infection among patients treated with gentamicin-coated nail during the follow up (X2 = 4.66, p = 0.031). At 6 months postoperatively, CRP (p = 0.031), ESR (p = 0.046) and hemoglobin level (p = 0.016) showed significant difference between two groups. The bone healing rate was better with gentamicin-coated nail in comparison to regular IMIL nail at 6 months follow-up (p = 0.016).ConclusionGentamicin-coated IMIL nail has a positive role in preventing infection in Gustilo type I and II open tibia fractures.
ABSRACT Motor vehicles are the prime source of transportation where vehicles with A/C play a major part. This paper designs an embedded system for a vehicle cabin, which senses the gases like carbon-monoxide and oxygen and displayed at each and every second. If the level of the CO increases than the normal level (30ppm) or the level of the oxygen decreases than the normal level (19%) then an alarm is generated automatically and also ventilation is provided immediately. A warning message is sent to the authorized user via GSM. The advantage of this system is proper detection and faster response time leading to faster diffusion of the situation, compared with the manual methods.
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