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The effects of the synthetic monocyte chemotactic protein-1 (MCP-1) peptide fragment 65-76 (peptide X) on the development of neointima after balloon injury to the carotid artery were studied. The agent was given i.m. at a dose of 33 microg/kg once daily for 28 days after balloon injury. Animals given peptide showed significant suppression of neointima growth 4 and 7 days after lesioning, as indicated by morphometric analysis of sections of lesioned arteries. On days 14 and 28, there were no significant differences in neointima formation in rats given and not given peptide. Peptide administration was not accompanied by any changes in C-reactive peptide concentrations, leukocyte counts, or the population composition of peripheral blood lymphocytes. Use of synthetic peptide X as an inhibitor of leukocyte migration during angioplasty may, along with traditional treatments, decrease the risk of restenosis.

The content of marker foxp3 of regulatory T cells and chemokines in atherosclerotic plaques of human coronary arteries was measured by the polymerase chain reaction. In vitro migration of regulatory CD4(+)CD25(+)foxp3(+) cells in the CD4(+) lymphocyte population from healthy donors was studied after treatment with chemokines I-309, IP-10, and SDF-1. mRNA for the factor foxp3 and chemokines SDF-1, I-309, and MIP-1beta were found in the majority of samples from atherosclerotic plaques. SDF-1 induced maximum migratory response of CD4(+)CD25(+)foxp3(+) cells.

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Abstract. The article briefly tells about the life and scientific work of professor, doctor of Technics, corresponding member of Russian Academy of Sciences Victor Aleksandrovich Soifer -an outstanding scientist in the field of diffractive optics and computer image processing. I analyze the jubilee contribution to the development of photonics, computer optics and image analysis systems.

Abstract. The author analyzes the contribution of Samara scientists into development of Computer Optics scientific journal. He briefly describes the stage of publication of the Computer Optics collection in Moscow. Particular attention is paid to Samara stage of the journal development, its results, and to journal articles that have attracted special interest of the research community. The author tells about the current progress of the journal, discusses the prospects for its development.

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The paper briefly describes the main achievements in the area of laser technologies and the application of diffractive computer optics of Academician of the Russian Academy of Sciences, Doctor of technical sciences, Professor, Honoured Scientist and Engineer of the RSFSR, Laureate of the State Award of the Russian Federation in the area of science and technology Vladimir P. Shorin.