Manganese oxides have been synthesized by the interaction of Mn 2+ and Mn in the presence of nanoreactors: cetyltrimethylammonium bromide micelles that were not present in the final product composition. The synthesized substance is investigated using scanning electron microscopy, X-ray diffraction analysis, dynamic light scattering, the Brunauer-Emmett-Teller method, and the method of Barrett-Joyner-Halenda. It is determined that the substance under examination is a filamentous nanometer-scale material with a cross-section size up to 100 nm. The acute inhalation toxicity study is performed according to the interstate standard using the method of acute-toxicity class determination (ATC method) (OECD, Test no. 436:2008, IDT). The ATC method allows us to see that synthesized nanosized manganese oxide has an acute toxicity property when inhaled as an aerosol. Upon 4-h exposure to Wistar rats weighing 190 ± 10g, CL 50 is 0.12 mg/L. The clinical picture of acute intoxication is characterized by irritation, neurotoxic effects, and respiratory depression. According to CL 50 (>0.05-0.5), mg/L criterion, synthesized nanosized manganese oxide belongs to hazard class 2 in accordance with Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
Abstract.Experimental research has shown that after intragastric administration of a water suspension of nanodispersed silicon dioxide particles synthesized by the method of templating the tested product falls in hazard class 3 by criteria LD50. A number of morphological changes were detected in the least researched dose of 500 mg/kg, in particular, gross changes in the blood circulatory system in the form of vascular distention, kidney, liver, and thymus. Other changes included lymphoid and macrophage proliferation and degenerative changes in the liver, kidney, splenic cords and lungs. After administration of a microdispersed analogue by the same method, no deaths of experimental animals were recorded (hazard class 4). A number of morphological changes were detected in dose 500 mg/kg including moderate vascular changes in liver, lymphoid proliferation, and lymphoid infiltration in the tissues of the esophagus, liver, kidney, large intestine, and gastric tissues.
The object of the study was amorphous silica dioxide (SiO 2 ), which is widely used as a food additive (E551), a subsidiary component in pharmaceutical preparations
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