In this work, surface enhanced Raman scattering (SERS) spectra of aspirin and ibuprofen molecules adsorbed on the surface of silver nets sputtered on porous silicon were collected and analyzed. The bands in the SERS-spectra were correlated in accordance with the type of molecular vibration. Predominantly chemical adsorption of the indicated drugs on the SERS-active substrate through oxygen was observed. It was established that the Raman spectroscopy combined with the SERS-active silver nets makes it possible to detect the aspirin and ibuprofen at 10-6 M concentration.
Silvered porous silicon was utilized as an active substrate for a detection of small amounts of meldonium by surface enhanced Raman scattering (SERS) spectroscopy. We were able to detect the meldonium in its water solutions at the concentrations of 10[Formula: see text]–10[Formula: see text][Formula: see text]M. Immersion of the silvered porous silicon in the meldonium solutions at the 10[Formula: see text][Formula: see text]M concentration and lower led to the dimers’ formation. At the concentrations larger than 10[Formula: see text][Formula: see text]M, a greater contribution to the enhancement of the Raman intensity was caused by a chemical mechanism while the smaller amounts were detected mostly due to an electromagnetic mechanism.
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