Detection of ibuprofen and aspirin on silver nets by surface enhanced Raman scattering (SERS) spectroscopy

Abstract

In this work, surface enhanced Raman scattering (SERS) spectra of aspirin and ibuprofen molecules adsorbed on the surface of silver nets sputtered on porous silicon were collected and analyzed. The bands in the SERS-spectra were correlated in accordance with the type of molecular vibration. Predominantly chemical adsorption of the indicated drugs on the SERS-active substrate through oxygen was observed. It was established that the Raman spectroscopy combined with the SERS-active silver nets makes it possible to detect the aspirin and ibuprofen at 10-6 M concentration.

100 GSM paper as an SERS substrate for trace detection of pharmaceutical drugs in an aqueous medium

“…Various groups have reported SERS-based detection of paracetamol where SERS substrates have been fabricated by drop-casting colloidal gold NPs (AuNPs) on to microscopic glass slides [58], by dispensing AuNPs on aluminium foil [59], by using molecularly imprinted polymers [60], or by lithography-free production of a transparent nanostructured surface [61]. Similarly, the detection of aspirin was performed on spiked urine samples by utilizing an in situ laser-induced photochemical silver substrate synthesized in a moving flow cell [62], in blood serum by the use of colloidal NP solutions of silver and gold [63], on silver nets sputtered on porous silicon [64], and by using NP-coated filter paper [65]. The limit of detection (LoD) was observed to be 0.1 mM for both the analytes, which is found to be superior to some of the earlier results reported elsewhere [58,63].…”