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Current research details methodological framework for the land planning of the recreational activities based on ecologic approach. Human impacts on landscapes caused by touristic activities should be in accordance with sustainability level, i.e. without changing natural landscape elements, their function and processes, as well as environmental quality. Region of Štiavnické Bane in Slovakia represents a case study area that is completely under nature and landscape conservation. The methodological framework for the planning of recreational activities is based on the methodology of ecologic carrying capacity which is implemented by the Landscape ecological planning. The main result from this work is suitable tourism activities determined by the ecological approach. Methodological steps include spatial analysis, interpretation, evaluations and propositions which were suggested for recreational activities. The most suitable activities for winter periods are downhill skiing, cross-country skiing and winter tourism. For the summer period the best activities are the following ones: hiking, water sports and recreational activities linked to watering and sport fishing. The most suitable activities for the year-round period are service facilities and therapeutic recreational facilities. This sum of the activities represents the level of the land using that has not any negative environmental impact.

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Results of our model indicate that fidaxomicin is a cost-effective therapy compared with vancomycin in patients with colitis induced by C. difficile if the outcome is life-year saved. However, if the outcome is the number of avoided colectomies, then fidaxomycin is not a cost-effective option compared with vancomycin.

Chimeric antigen receptor T (CAR T) cell therapy achieved remarkable success in B-cell leukemia and lymphoma which led to its incorporation in treatment protocols for these diseases. CAR T cell therapy for chronic lymphocytic leukemia (CLL) patients showed less success compared to other malignant tumors. In this review, we discuss the published results regarding CAR T cell therapy of CLL, possible mechanisms of failures and expected developments.

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