In eight wife-husband pairs during the whole pregnancy the reactivity of lymphocytes to PHA, to lymphocytes of unrelated donor and to lymphocytes of husband was studied. No statistically significant differences were found in reactivity of wife's and husband's lymphocytes. In eleven women at delivery a statistically significant decline of MLC reaction to lymphocytes of own and unrelated newborn was found, while the reactivity to PHA and to lymphocytes of unrelated adult donor remained unchanged. Similarly, the lymphocytes of eleven newborn infants reacted statistical significantly less to lymphocytes of own mother and unrelated mother, while the reaction to PHA and to lymphocytes of unrelated donor was well expressed.
Summary
By use of staining with toluidine blue, the changes in the nucleoli of lymphocytes in 150 healthy women were studied. The patients were divided into five groups: non‐pregnant women; women in the first, second and third trimesters of pregnancy; and women who were five days post parturn. A progressive and statistically significant rise in the number of lymphocytes with micronucleoli was found during pregnancy and there was a fall after delivery. This increase was associated with a decrease in the incidence of ring‐shaped nucleoli. There were no significant changes in the absolute number of lymphocytes and in “active” lymphocytes during pregnancy.
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