Feto-maternal relationship in normal pregnancy in mixed lymphocyte cultures

Abstract

In eight wife-husband pairs during the whole pregnancy the reactivity of lymphocytes to PHA, to lymphocytes of unrelated donor and to lymphocytes of husband was studied. No statistically significant differences were found in reactivity of wife's and husband's lymphocytes. In eleven women at delivery a statistically significant decline of MLC reaction to lymphocytes of own and unrelated newborn was found, while the reactivity to PHA and to lymphocytes of unrelated adult donor remained unchanged. Similarly, the lymphocytes of eleven newborn infants reacted statistical significantly less to lymphocytes of own mother and unrelated mother, while the reaction to PHA and to lymphocytes of unrelated donor was well expressed.

Changes in cytokine production and composition of peripheral blood leukocytes during pregnancy are not associated with a difference in the proliferative immune response to the fetus

“…Because we performed HLA typing before proliferation, we had to use frozen cells, which is a drawback of this study. Our results confirm an earlier study in which reactivity of mPBMC to a woman's own and unrelated newborn lymphocytes was not different [37]. Steinborn et al showed reduced responses in MLR to a woman's own child compared with control donors [38].…”

Cell‐Mediated Immunity in Human Pregnancy

“…While some investigators have claimed that the maternal immunological response to mitogens or allogeneic lymphocytes is depressed during pregnancy (6,10,12,18,20,25,27), other workers have found no difference in the immunological responses between pregnant and nonpregnant women (4,11,15,24,26). Variations in materials and methodology in different laboratories may be responsible for the disparity.…”