The feto-maternal lymphocyte interaction in preeclampsia and in uncomplicated pregnancy

Gille, Jens; Williams, Jon L.; Hoffman, Camille

doi:10.1016/0028-2243(77)90074-0

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1979

1995

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Cited by 14 publications

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“…In a longitudinal study stored lymphocytes from one patient who developed preeclampsia showed depressed responses to PHA, PPD and Escherichia coli antigen preceding the onset of pre-eclampsia (Birkeland & Kristoffersen 1979). Lymphocytes from pre-eclamptic women also show reduced transformation in mixed lymphocyte cultures with paternal or fetal cells (Hallbrecht & Komlos 1974;Gille et al 1977;Jenkins ef al. 1978).…”

Section: Discussionmentioning

confidence: 99%

Lymphocyte subsets in normal and pre‐eclamptic pregnancies

Moore

Carter

Redman

1983

BJOG

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Peripheral blood lymphocyte subsets in normal and preeclamptic pregnancies have been studied by using the monoclonal antibodies OKT3 (T cells), OKT4 (helper/inducer T cells) and OKT8 (suppressor/cytotoxic T cells). In addition the numbers of mononuclear cells bearing l a and monocyte antigens have been assessed by using the monoclonal antibodies O K I a l and O K M 1. No significant differences were found between 10 normal pregnant and 10 non-pregnant subjects. Ten preeclamptic patients were studied and showed an increase in OKT4-positive helper cells. This was significant in terms of percentage of mononuclear cells but not the absolute numbers or the helper/suppressor

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Section: Discussionmentioning

confidence: 99%