Synthesis and Anticholinesterase Properties of Diacetylene Diamines.-All diacetylene diamines (VI), synthesized by Mannich reaction of α,ω-diacetylenes with amines and formaldehyde, possess non-selective anticholinesterase activity. It is shown, that the biological activity is reduced in sterically strained tertiary amines like N-benzyl derivative (VIc). Introduction of a diphenylpolymethylene bridge [cf. compound (VIb)], however, increases the activity. -(LIBMAN, N. M.; KUZNETSOV, S. G.; ZLOBINA, V. I.; MORALEV, S. N.; KORMILITSYN, B. N.; ANDROSOV, N. S.; Khim.-Farm. Zh. 32 (1998) 9, 20-22; Inst. toksikol. Minzdravmedproma Rossii, St. Petersburg, Russia; RU)
Die Dehydratisierung des Tertraphenylbutadienols (II) in siedendem Eisessig (auch in siedendem äthanolischem H2SO4 oder in siedendem Acetanhydrid) liefert glatt das Phenyldiphenylmethyleninden (I).
Alkylierungen der aus dem Brombuten (I) unter der Einwirkung von Alkalimetallamiden entstehenden Salze (II) mit Alkylhalogeniden liefern ausschließlich die Acetylene (III).
Reaktionen des Di‐Li‐derivates (I) des 3,3‐Diphenyl‐propins (analog auch des Di‐Naderivates ) in flüssigem NH3 mit den Ketonen (II) liefern über die Stufe der Alkoholate (III) die Allencarbinole (IV).
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