ChemInform Abstract: Synthesis and Anticholinesterase Properties of Diacetylene Diamines.

Abstract

Synthesis and Anticholinesterase Properties of Diacetylene Diamines.-All diacetylene diamines (VI), synthesized by Mannich reaction of α,ω-diacetylenes with amines and formaldehyde, possess non-selective anticholinesterase activity. It is shown, that the biological activity is reduced in sterically strained tertiary amines like N-benzyl derivative (VIc). Introduction of a diphenylpolymethylene bridge [cf. compound (VIb)], however, increases the activity. -(LIBMAN, N. M.; KUZNETSOV, S. G.; ZLOBINA, V. I.; MORALEV, S. N.; KORMILITSYN, B. N.; ANDROSOV, N. S.; Khim.-Farm. Zh. 32 (1998) 9, 20-22; Inst. toksikol. Minzdravmedproma Rossii, St. Petersburg, Russia; RU)

10.1007/s11176-008-1019-9

“…Libman et al [23] proved by 1 H NMR spectroscopy that the o,o`and m,m`protons in different rings of the diphenylmethane (I) molecule are mutually equivalent, which is best consistent with the conrotatory mutual orientation of the rings. According to the IR data [24], the angles of the ring turn in this molecule are 51o for the conrotatory conformation.…”