The aim of the present work was to study the causes and structure of interictal cognitive and emotionalpersonality impairments in children with different types of epilepsy. A total of 40 children were studied, aged from eight to 18 years. Symptomatic epilepsy was diagnosed in 31 patients (77.5%) and idiopathic epilepsy in nine (22.5%). Cognitive functions were compared in relation to the type of epilepsy, type of seizures, and treatment with antiepileptic and its efficacy. The results showed that intellectual-mnestic disorders were seen in 62% of children with epilepsy, more profound impairments being seen in patients with generalized epileptic seizures. Achievement of stable remission from seizures was associated with good recovery of cognitive functions; in the absence of treatment with antiepileptic agents and when treatment was ineffective, there were marked disorders to the intellectual-mnestic sphere.
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The large number of antiepileptic drugs (AEDs) at the physician's disposal provides not only a broad therapeutic potential in the treatment of epilepsy (EP), but creates difficulties in the adequate choice of AED. The sufficient experience in the management of patients with epilepsy has been gained so far in the world, based on which the International League Against Epilepsy (ILAE), updated classification, adopted the basic definition of efficiency, remission, resistance, evidence of research on the effectiveness of AED therapy, and introduced the concept of "resolved" epilepsy. In this article, a group of Russian experts suggest recommendations on the main steps in the choice of therapy in epilepsy. Possible drug interactions between different AEDs and other drugs as well as main characteristics of mono- and polytherapy of epilepsy are described. Some features of the use of AEDs in the elderly, characteristics of the "female" epilepsy related to the reproductive function and basic requirements for the therapy of epilepsy in children are presented.
Prader–Willi’s syndrome is a genetic anomaly which often masks under cerebral spastic infantile paralysis and myopathy diagnoses. Though at careful collecting the anamnesis, attentive survey of the patient and competent genetic inspection the diagnosis usually doesn’t raise doubts.
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