Characteristics of Cognitive Functions in Children with Epilepsy

Guzeva, V. I.; Белаш, В. О.; Guzeva, V. V.; Guzeva, O. V.; Anastazi, Okembra Ibarra Eleonora

doi:10.1007/s11055-009-9205-8

Cited by 13 publications

(8 citation statements)

References 2 publications

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“…For example, Sharma et al [11] concluded that gender had no impact on neurological and psychological deficits among epileptic children. Other comparable results, such as Hoare and Kerley [29], found gender difference to be inconsistent as a predictor of psychological problems in children with epilepsy. Studies that found sex to predict cognitive functions have shown that male epileptic children had more neurological deficits than their female counterparts, but female epileptic children had higher mean psychological deficits.…”

Section: Discussionmentioning

confidence: 77%

“…Other similar results show that gender is inconsistent as a predictor of psychological problems in children with epilepsy. Hoare and Kerley [29] found no gender difference but Austin et al [30] found that boys had more problems than girls, whereas a previous study of children with chronic epilepsy by Austin et al showed that girls with more severe seizures had the most difficulties.…”

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confidence: 98%

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Intellectual Function among Epileptic Children: The Role of Epilepsy Related-Factors in Nigeria

On¹

2013

IOSR-JHSS

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This study evaluated the role of epilepsy-related factors, such as etiological variability, sex and age, on general intellectual functions among Nigerian children with epilepsy. Sixty epileptic children (38 males and 22 females) with a mean age of 12.9 years (SD= 2.9 years) were randomly selected from a population of epileptic children attending the Outpatient Neurology Clinic at Neuropsychiatric Hospital, Aro, Abeokuta. The Wechsler Intelligence Scale for Children (WISC-R) was administered. The result showed that 73.4% of the epileptic children had mental retardation, borderline and low average IQ level which, in some way, corresponded to general intellectual impairment. Multiple regression analysis revealed that etiological variability independently predicted Verbal IQ, Performance IQ and Full Scale IQ among the epileptic children. Furthermore, sex independently predicted Performance IQ of the epileptic children. This study emphasised a significant joint prediction of etiological variability, sex and age on Verbal IQ, Performance IQ and Full Scale IQ among the epileptic children. In conclusions, etiological variability and sex are important predictors of general intellectual functions. This research will enhance the understanding of those epileptic children who are in danger of developmental impairment so that treatment methods can be developed.

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Section: Discussionmentioning

confidence: 77%

mentioning

confidence: 98%

Intellectual Function among Epileptic Children: The Role of Epilepsy Related-Factors in Nigeria

On¹

2013

IOSR-JHSS

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“…Seu tratamento correto envolve muitas questões além do controle das crises, incluindo aspectos cognitivos e sociais 2 . É bastante comum que crianças com epilepsia tenham dificuldades de aprendizagem e déficits cognitivos 3 . Os problemas cognitivos dos pacientes com epilepsia são multifatoriais, incluindo fatores clínicos e demográficos, como: idade de início, frequência das crises, tipo de crise, causa da epilepsia, drogas antiepilépticas e duração da epilepsia 4 .…”

Section: Funcionamento Intelectual Em Pacientes Pediátricos Com Epileunclassified

Intellectual functioning in pediatric patients with epilepsy: a comparison of medically controlled, medically uncontrolled and surgically controlled children

Souza-Oliveira¹,

Escosi-Rosset²,

Funayama³

et al. 2010

J Pediatr (Rio J)

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Objective: To compare the intellectual coefficient (IQ) of three groups of children with epilepsy: 1) medically controlled, 2) medically uncontrolled and 3) surgically controlled. Methods:From December 2007 until July 2008, 98 pediatric patients were selected, with an age range between 6 and 12 years. Neuropsychological assessment included the Wechsler Intelligence Scale for Children -third edition (WISC-III). Results are related to epileptic syndrome, etiology of epilepsy, drug therapy, age at epilepsy onset and epilepsy duration.Results: WISC scores were significantly better in the medically controlled group when compared to the medically uncontrolled group. The medically controlled group performed significantly better in the majority of the WISC subtests when compared to medically uncontrolled group: vocabulary, arithmetic, comprehension, digit span, picture completion, picture arrangement, and block design. A significantly higher number of idiopathic epilepsy and monotherapy cases was observed in the medically controlled group when compared to the medically uncontrolled group. Surgically controlled children had no significant differences in IQ performance when compared to medically controlled children. Conclusions:Children with good seizure control have higher general, verbal and performed intelligence when compared to children with refractory epilepsy. These results may be influenced by clinical factors such as use of monotherapy, drug type and epileptic syndrome and etiology. Epilepsy surgery can have a positive impact on cognitive performance of children who were free of seizures after surgery. J Pediatr (Rio J). 2010;86(5):377-383:Epilepsy, children, neuropsychology. ResumoObjetivo: Comparar o quociente intelectual (QI) em três grupos de crianças com epilepsia: 1) controlados com medicação, 2) não controlados com medicação e 3) controlados com cirurgia.Métodos: Noventa e oito pacientes pediátricos, com idades entre 6 e 12 anos, foram selecionados de dezembro de 2007 a julho de 2008. A Escala de Inteligência Wechsler para Crianças -terceira edição (WISC-III) foi utilizada para a avaliação neuropsicológica dos pacientes. Os resultados foram relacionados com a síndrome epiléptica, a etiologia da epilepsia, o tratamento medicamentoso, a idade do paciente no início da epilepsia e a duração da epilepsia.Resultados: Os escores da WISC foram significativamente melhores no grupo controlado com medicação quando comparados aos do grupo não controlado com medicação. O grupo controlado com medicação obteve um desempenho significativamente melhor na maioria dos subtestes da WISC quando comparado ao grupo não controlado com medicação: vocabulário, aritmética, compreensão, memória de dígitos, completar figuras, arranjo de figuras e cubos. Um número significativamente maior de pacientes com epilepsia idiopática e uso de monoterapia foi observado no grupo controlado com medicação quando comparado ao grupo não controlado. O grupo controlado com cirurgia não apresentou diferença significativa no desempenho do QI qua...

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“…Epilepsy is a common pediatric problem, and of considerable challenge to pediatricians [1,2]. Epilepsy can severely affect the development and function of immature brain, which may lead to cognitive or intellectual dysfunctions.…”

Section: Introductionmentioning

confidence: 99%

Gray matter abnormalities in pediatric focal and generalized epilepsy: A voxel-based morphometry study with MRI at 3.0 T

zhang

Liu

Chen

et al. 2019

Preprint

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Background : Our aims were to explore gray matter volume (GMV) abnormalities in focal and generalized epilepsy children compared to healthy group using a voxel-based morphometry (VBM) methodology, and to determine whether the regions of any observed structural changes are correlated with clinical characteristics. Methods: Thirty-two epilepsy children ( 18 with focal epilepsy, 14 with generalized epilepsy) and 18 control subjects were recruited. All participants were imaged structural MRI scans with a 3.0 T MR system. VBM analysis using statistical parametric mapping 8 (SPM8) was first performed to detect gray matter reduction in focal and generalized epilepsy children compared to controls. Then we analyzed the correlations between GMV changes and clinical features of epilepsy patients. Results: In the patient-control group comparison of VBM, the left hippocampus, left thalamus, left paraHippocampal and bilateral putamen exhibited a significantly GMV decreased. In stratified analysis, the focal epilepsy children showed GMV reductions in left thalamus, left hippocampus and bilateral putamen relative to controls; the GMV exhibited extensive reductions in left parahippocampal, left putamen, and right supplementary motor area in generalized epilepsy children compared to controls. No significant difference was found in regions of GMV abnormalities correlated with disease durationand age of onset in both the focal and generalized epilepsy groups. Conclusions: By performing VBM to detect GMV changes in children, our study demonstrates the GMV reductions exist in different regions in focal and generalized epilepsy patients. Our study further provides structural neuroimaging evidence on the pathophysiology of focal and generalized epilepsy children.

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Characteristics of Cognitive Functions in Children with Epilepsy

Cited by 13 publications

References 2 publications

Intellectual Function among Epileptic Children: The Role of Epilepsy Related-Factors in Nigeria

Intellectual Function among Epileptic Children: The Role of Epilepsy Related-Factors in Nigeria

Intellectual functioning in pediatric patients with epilepsy: a comparison of medically controlled, medically uncontrolled and surgically controlled children

Gray matter abnormalities in pediatric focal and generalized epilepsy: A voxel-based morphometry study with MRI at 3.0 T

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