The article deals with the method of preparation of the liniment, the type of oil solution, based on thio-derivative of triazole. In order to determine the degree of the solution of the investigating substance in the Saint-Marry-thistle (silybum marianum) oil, other physical properties (capacity to stratification, hydrophilicity) and antimicrobial, antifungal action, the medical forms of the concentration at 1, 3, 5, 7, 10, 12, 15% were made. For the preparation of non-lethal oil solution,it was used the classical technology with the loading of the solvent in the order of increasing viscosity or density. The active substance weighed on the analytical scales (PCR-246) was put in dry bottles and was filled with the calculated mass of the thistle oil. To provide faster dissolution of the chemical compound in the oil, the vial was heated in a water bath (40–50 °C). It has been established that the new-synthesized compound is well soluble in thistle oil in the forms at 1, 3, 5 and 7%. The obtained solutions were marked by transparency, lack of sediment in the haze. The critical limit of solubility was 10% solution. For moderate solubility and light clouding, such crystallization was typical for such solutions, which disappeared in 10–15 minutes on the condition of heating it in a water bath 18–20 °C). At higher concentrations (12 and 15%) the investigated chemical compound was littlesoluble and insoluble, precipitated (felt out in sediment) and crystallized. The concentration of the solution (1, 3, 5 and 7%) was characterized by resistance to bundle. For 10% solutions of the investigating dosage form, there was a slight stratification with signs of crystallization on the verge. Sorbent capacity of oil solutions is insignificant and stops after 2 hours. According to the assessment of the effect of the new- developed therapeutic agent on microorganisms and fungi, a deleterious effect on S. aureus and C. albicans and A. niger was noted, which provides the basis for preclinical studies on laboratory animals, especially with the patterns of solution at 7 and 10% concentration.