Cluster of differentiation 151 (CD151) is a member of the mammalian tetraspanin family, which is involved in diverse functions such as maintaining normal cellular integrity, cell-to-cell communication, wound healing, platelet aggregation, trafficking, cell motility and angiogenesis. CD151 also supports de novo carcinogenesis in human skin squamous cell carcinoma (SCC) and tumor metastasis. CD151 interacts with α3β1 and α6β4 integrins through palmitoylation where cysteine plays an important role in the association of CD151 with integrins and non-integrin proteins. Invasion and metastasis of cancer cells were diminished by decreasing CD151 association with integrins. CD151 functions at various stages of cancer, including metastatic cascade and primary tumor growth, thus reinforcing the importance of CD151 as a target in oncology. The present review highlights the role of CD151 in tumor metastasis and its importance in cancer therapy.
Background: During performing orotracheal intubation with direct laryngoscopy adequate laryngeal visualization depends on proper airway maneuvers. There are different types of airway maneuvers.
Aims and Objectives: This study aimed to compare airway maneuvers; manual in line stabilization (MILS), jaw thrust, and conventional maneuver to assess better laryngeal visualization and ease of intubation among them and associated complications.
Materials and Methods: This observational study was conducted in 90 adult patients. Patients divided into three groups. Laryngoscopy and intubation in Group M were done in MILS and in group J jaw thrust. In Group C, as conventional maneuver performed. Laryngeal visualization assessed using modified Cormack–Lehane grading and ease of intubation assessed using intubation time, number of attempts between these three groups. The data were compared using ANOVA test, Chi-square test.
Results: While comparing between these groups better laryngeal visualization seen in jaw thrust group, while the MILS maneuver worsen the view.
Conclusion: The present study concluded that jaw thrust maneuver improved the laryngeal visualization and conventional maneuver made intubation faster and easy.
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