CD151—A Striking Marker for Cancer Therapy

Kumari, Seema; Devi, V. Gayatri; Badana, Anil Kumar; Dasari, Venkata Ramesh; Malla, Rama Rao

doi:10.4137/bic.s21847

Cited by 40 publications

(25 citation statements)

References 59 publications

(72 reference statements)

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“…As an oncogene, CD151 not only supports growth of various types of tumors but also regulates tumor cell spreading, migration and invasion [26, 36–38] and facilitates metastatic process [39]. Our data demonstrated an oncogenic role of CD151 in HCC cells, in which CD151 enhances proliferation, migration and invasion.…”

Section: Discussionmentioning

confidence: 65%

PIK3C2A mRNA functions as a miR-124 sponge to facilitate CD151 expression and enhance malignancy of hepatocellular carcinoma cells

Liu

Wang

et al. 2016

Oncotarget

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Competing endogenous RNAs (ceRNAs) are RNA transcripts that can crosstalk with each other by competing for shared microRNAs (miRNAs) through miRNA response elements (MREs). Involved in ceRNA networks, the RNA transcripts may be in a balance, disruption of which could lead to tumorigenesis. Here we reveal a ceRNA interaction between PIK3C2A and CD151 mRNAs in hepatocellular carcinoma (HCC) cells. PIK3C2A is a candidate ceRNA of CD151 because mRNA 3′ untranslated regions (3′UTRs) of these two genes contain miR-124 binding sites. miR-124 is downregulated, while PIK3C2A and CD151 are upregulated in HCC cells compared with normal hepatocytes. Direct and negative regulation of PIK3C2A and CD151 by miR-124 was confirmed in HCC cells. miR-124 and the two potential ceRNAs are all recruited to the RNA-induced silencing complex (RISC). In HCC cell lines QGY- 7703 and SMMC-7721, and normal hepatic cell line HL-7702, miR-124 plays a tumor suppressor role by targeting PIK3C2A and CD151. The MREs within PIK3C2A 3′UTR can independently stimulate CD151 expression level by acting as miR-124 decoys. PIK3C2A MREs enhance HCC cell malignancy by absorbing endogenous miR-124 and activating CD151 in HCC cells. We conclude that PIK3C2A 3′UTR functions as a trans activator to stimulate CD151 by competing for miR-124 binding in HCC cells. The collaboration of PIK3C2A and CD151 through ceRNA mechanism may be implicated in HCC initiation and development.

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Section: Discussionmentioning

confidence: 65%

PIK3C2A mRNA functions as a miR-124 sponge to facilitate CD151 expression and enhance malignancy of hepatocellular carcinoma cells

Liu

Wang

et al. 2016

Oncotarget

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“…Reprogrammed target cells assist premetastatic niche formation. Some of the major tetraspanins which are associated with exosomes and promote cancer cell motility, invasion, metastasis, tumor initiation, promotion, progression and angiogenesis include CD9, CD8, CD82 and CD151 . In view of the functional role of tetraspanins in the biogenesis, cargo selection, protein and RNA sorting, targeting and uptake, they also have a great therapeutic value.…”

Section: Introductionmentioning

confidence: 99%

Exosomal tetraspanins as regulators of cancer progression and metastasis and novel diagnostic markers

Malla

Pandrangi

Kumari

et al. 2018

Asia-Pac J Clncl Oncology

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Exosomes are cell-cell communicators emerging as a new paradigm for noninvasive diagnosis and prognosis of treatment response. Exosomal tetraspanin proteins like CD63, CD9 and CD81 play a critical role in sorting, selective recruitment of biomolecules, target selection, cell-specific entry, capturing, angiogenesis and vasculogenesis. These tetraspanins are being used as markers for oral, colorectal and colon cancers and glioblastoma. However, exosomal markers with robust specificity for early detection of carcinomas are the furthest along. EXO CARTA database shows the presence of CD151 in exosomes of colorectal, melanoma, ovarian and prostate cancers. CD151 preferentially targets exosomes to lung, lymph node and stroma cells. The present review discussed the possible role of tetraspanins in the formation, cargo selection, target selection and uptake of exosomes and suggests exciting new directions for future research.

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“…Plasma membrane [69,73] Claudin-2 Membrane protein, Tissue enhanced (brain, gallbladder, kidney, liver, seminal vesicle) HDAC inhibitors elevate miR-497 expression and concomitantly decrease claudin-2 levels; resulting in decreased cell proliferation.…”

Section: Cell-cell Adhesionmentioning

confidence: 99%

Novel therapeutic targets for cancer metastasis

Stoletov

Beatty

Lewis

2020

Expert Review of Anticancer Therapy

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Introduction: Metastatic cancers are extremely difficult to treat, and account for the vast majority of cancer-related deaths. The dissemination of tumor cells to distant sites is highly dynamic, asynchronous, and involves both tumor and host intrinsic factors. Effective therapeutic targets to block metastasis will need to disrupt key pathways that are required for multiple stages of metastasis. Areas covered: This review discusses the heterogeneity of cancers and metastasis, with an emphasis on motility as a key driver trait of metastasis. Recent metastatic cancer studies that identified either host or cancer cell intrinsic factors important for metastasis, using single gene-deficient animal models or 3D intravital imaging of avian embryo models, are also discussed. Potential metastatic blocking targets are listed as they relate to metastatic cancer therapy. Expert opinion: The development of metastatic disease is a complex interplay of genetic and epigenetic factors from the host and cancer cells acting in a patient-specific manner. Inhibiting key driver traits of metastasis should yield survival benefit at any stage of the disease, and we look forward to the next generation of personalized medicines for cancer therapy that target cancer cell motility for increased therapeutic efficacy. ARTICLE HISTORY

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CD151—A Striking Marker for Cancer Therapy

Cited by 40 publications

References 59 publications

PIK3C2A mRNA functions as a miR-124 sponge to facilitate CD151 expression and enhance malignancy of hepatocellular carcinoma cells

PIK3C2A mRNA functions as a miR-124 sponge to facilitate CD151 expression and enhance malignancy of hepatocellular carcinoma cells

Exosomal tetraspanins as regulators of cancer progression and metastasis and novel diagnostic markers

Novel therapeutic targets for cancer metastasis

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