In this paper, a mathematical model for a membrane based amperometric biosensor is developed. The model is based on a diffusion mechanism related to Michaelis-Menten kinetics. The model is developed for an intensive stirred condition, so it has been assumed that the thickness of the diffusion layer is negligible. The model can be used to investigate the regularities and kinetics of the amperometric biosensor, and to develop any simulation methods to study the biosensor. The model shows that current I(t) generated during the specific biosensor enzymatic reaction mainly depends on the number of electrons generated and the area of working electrode. The model also describes the effect of background current in the biosensor. The validity of the developed model has been verified by designing a computer based instrumentation system for the amperometric biosensor. Repeated real time experiments were carried out, and the results obtained are in excellent agreement with the amount determined by high performance liquid chromatographic technique (HPLC), with an accuracy of +/-1.5%.
Sensors are used for providing a system with needed data considering some features of interest in the environment of system. Multi-sensor fusion would provide more accurate and reliable information. Multi-sensor fusion would be beneficial in numerous ways such as timeliness, redundancy, complementarily and so on. The main purpose of the research is to examine the biological sensor performance validation using data fusion technique. The fusion or integration of simulated sensor would minimize overall uncertainty and thus helps to maximize the accuracy. It would provide redundant data and also serve to maximize reliability in terms of sensor failure or error. The implementation would be performed in two phases such as data fusion approach and neural network approach. The code would be executed in the MATLAB. Glucose sensor and sucrose sensor were used as the biological sensor. Fusion method used is the state-vector fusion method and a Kalman filter and H-infinity based filter are implemented for enhancing the performance of data fusion algorithm. Simulate the sensor network and deploy the algorithm of data fusion and use neural network for validating the faulty of the sensor network. From the analysis, it was noticed that when compared to simulated stated sensor output, the simulated fused sensor output and target performs well. It was also observed that error rate also minimal in the simulated fused sensor. Further, Future work would be based on validating the biological and cognitive sensor performance through other fusion models.Key words: multi-sensor fusion, biological sensor, data fusion approach, fused sensor, neural network approach, simulated fused sensor and simulated stated sensor
The biological sensor has played a significant and contributory role in the area of medical science and healthcare industry. Owing to critical healthcare usage, it is essential that such type of sensors should be highly robust, sustainable under the adverse condition and highly fault tolerant against any forms of possible system failure in future. A massive amount of research work has been done in the area of the sensor network. However, works done in biological sensors are quite less in number. Hence, this manuscript highlights all the significant research work towards the line of discussion for evaluating the effective in the techniques for performance evaluation of biological sensor. The study finally explores the problems and discusses it under research gap. Finally, the manuscript gives highlights of the future direction of the work to solve the research gap explored from the proposed review of the existing system.
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