The constructed avirulent biplasmid Vibrio cholerae strain KM182 pro ducing cholera toxin B subunit and Escherichia coli colonization factor CFA/1 (providing for antitoxic and anti-colonization immunity formation, correspon dently) was demonstrated to protect immunized model laboratory animals from experimental cholera caused by the virulent Vibrio cholerae O139 strain. The optimal doses for immunization and challenging were determined.
Presented are the results of the field trial of the mobile laboratory in different landscape and climatic zones and seasons (spring, summer, autumn, winter). Determined are performance characteristics of the mobile module while carrying out indication of bacterial and viral nature germs and express-diagnostics of dangerous infectious diseases in field conditions. Communication I contains data on approbation of the mobile laboratory in spring-summer period.
Data on adaptive-compensatory process formation in detoxication and adaptation functional systems of test animals during the plague infection modeling were obtained by means of morphometric analysis. The latter included characterization of apudocytes condition in the number of organs. Changes of apudocytes activity and quantity in immunocompetent organs and pulmonary tissue of biomodels were determined. Morphometric indices selected for registration were shown to allow characterizing the severity of experimental infectious process.
Presented is the information on technical and medical trials of new generation preparations for gene diagnostics of Dengue fever and cholera, based on the multiple factor analysis. Application of these preparations makes it possible not only to detect pathogen but also to carry out its expedited identification in accordance with epidemiological significance and taxonomic status.
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