SynopsisPolynucleotide analogs with polytrimethylenimine backbones and optically active 2-(thymin-l-y1)propionic acids as pendants were prepared. Linear polytrimethylenimines were obtained by ring-opening polymerization of 2-phenyl-5,6-dyhydro-4H-1,3-oxazine and subsequent hydrolysis of the resulting polymers. 2-(Thymin-l-yl)propionic acids were reacted with N-hydroxy succinimide to form active esters. Optical purities of active esters were determined by NMR with chiral chemical shift reagents. The polynucloetide analogs and related monomer and dimer model compounds were prepared by grafting reactions using active esters.
°C [pure by TLC (silica, 1:4 EtOAc/petroleum ether)].Acknowledgment. Support of this work by the National Institutes of Health (Grant CA 17631) is gratefully acknowledged. We thank Professors B. Franck7 and L. A. Mitscher for exchange of information and Dr. A. Bonati for a gift of emodin.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.