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SUMMARY:The multiplicity of meningiomas or abrupt lesion growth in patients treated with cyproterone acetate suggests that this progestative treatment may promote lesion growth. We report the rapid regression of an incidental meningioma after discontinuation of a 10-year cyproterone acetate treatment. This unique observation suggests that conservative management of meningiomas may be the best option among users of high doses of cyproterone acetate, given that spontaneous regression may occur after hormonal treatment discontinuation.ABBREVIATIONS: FLAIR ϭ fluid-attenuated inversion recovery C yproterone acetate is a synthetic progestin with a powerful antiandrogen property, which is indicated for the treatment of inoperable prostate carcinoma, the reduction of sexual drive in men, or severe signs of androgenization in women. It is occasionally prescribed in male-to-female transsexual patients. It is also found in smaller quantities in combined oral contraceptives and for treating seborrhea, acne, hirsutism, and moderate androgen-related alopecia. Recent observations of meningioma, often multiple, among users of high doses of cyproterone acetate have raised the suspicion that it may promote the rapid growth of pre-existing or new meningioma.

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