SUMMARY This study aimed to evaluate the efficacy of the action of the Lactobacillus Plantarum probiotic as a immunomodulatory and hypolipidemic agent in dyslipidemic nephrotic children and adolescents. METHODS: This is a randomized, double-blind, placebo-controlled clinical trial in pediatric, compensated or partially compensated nephrotic syndrome and dyslipidemic subjects undergoing regular outpatient follow-up. Serum lipid and TNF-α (proinflammatory) and IL-10 (anti-inflammatory) cytokine variations were evaluated. Cytokines were analyzed by enzyme-linked immunosorbent assay (ELISA). RESULTS: In the probiotic group there was a tendency to reduce TNF-α levels and increase IL-10 levels when compared to controls. Regarding the lipid profile, there was a decrease in serum triglyceride (6.0 mg / dL) and total cholesterol (41.5 mg / dL) levels in the probiotic group when compared to baseline levels, while in the control group there was an increase in serum triglyceride (49.5 mg / dL) and total cholesterol (8.0 mg / dL) levels, respectively. CONCLUSION: Preliminary results suggest that L. Plantarum showed an immunomodulatory and hypolipidemic effect in nephrotic and dyslipidemic pediatric subjects.
descriptive statistics. Results: 2303 cases of breast cancer in woman were registered on these cities. The average age of women with a breast cancer diagnosis was 55 years, and pertaining relationship status, a little over 42% fitted the not single category, and over 43% had no data. About the skin color, 37.06% were white and over 39% had not filled this variable on the record. About the tumor aspects related to the disease's extension, we identified that in over 48% of the cases the tumors were classified as localized, over 23% as regional and only 4.23% as distant. About the tumor's side, over 33% had no information, 31.04% were located at the right side and 33.40% at the left side. About the tumor's type most cases, 85.5%, were invasive ductal carcinoma, 4.6% ductal carcinoma in situ, 2.6% invasive lobular carcinoma and only 0.30% lobular carcinoma in situ. 106 cases had no information about the tumor's type. Conclusion: This study's goal was a better comprehension about this disease's effect on the patients: it's evolution, association with risk factors, presence of metastasis and mortality.
Objective: To evaluate the clinical quality of mammograms performed in users of the Unified Health System (SUS), referred to a tertiary hospital. Methods: A prospective study whose unit of observation was the mammograms of women referred for consultation in a Breast Cancer Resource Center, located in the city of Goiânia, Brazil, from May to October 2017. Mammograms for screening or for diagnosis were included, performed within six months prior to study inclusion. The clinical quality of the mammograms was evaluated using 40 variables per exam, related to the identification, the technique of the exam, the executing equipment, the radiological findings, the exam report and the mammary positioning. For these last variables, a comparison was made according to the origin of the exam (public vs. private network). Results: A total of 4560 items of clinical image quality were evaluated in 114 women whose mean age was 50.6 years. Of the total items analysed, there were 660 failures (14.47%), and 443 (67.12%) failures were related to breast positioning. Among the positioning failures, the absence of visualization of the pectoralis major muscle (86.8%) and the inframammary sulcus (79.8%) in the CC and MLO incidences, respectively, were the most frequent. Considering the positioning criteria evaluated in the MLO incidence, the examinations performed in the private network presented a higher risk of failures related to the nipple centered (RR 4.66, 95%CI 1.05-20.62, p=0.02) and the visualization of the retro-mammary fat (RR 4.14; 95%CI 0.92-18.66, p=0.04), in relation to the exams performed in the public network. Conclusion: The mammograms analysed presented an inadequate quality pattern, with predominance of non-compliance related to breast positioning.
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