Laboratory and clinical efficacy of the combinations of neuroprotective and antioxidant drugs in DE reduced in the following order: actovegin and cereton → emoxipine and piracetam → cerebrolysin and mexidol.
The paper presents experts' opinion on the clinical manifestations and diagnosis of chronic cerebrovascular disease (CVD) (chronic cerebral ischemia (CCI) and dyscirculatory encephalopathy (DEP)) at the pre-dementia stage. It is noted that DEP/CCI is a common diagnosis in Russian neurological practice, the criteria for which have not been updated for a long time. DEP/CCI most often develops in the presence of cerebral small artery (CSA) disease (cerebral microangiopathy (CMA)), the severity of which can be quantified by magnetic resonance imaging. The main clinical manifestation of DEP/CCI is cognitive impairment that may be subjective or moderate at the pre-dementia stage. Emotional disorders (apathy, depression, anxiety) and instability are considered as possible manifestations of CSA disease. It is noted that headache and vestibular vertigo are not caused by chronic CVD; while in patients with CMA, they are usually associated with other diseases (primary headache, peripheral vestibular vertigo, and vestibular migraine). The diagnosis of DEP/CCI should be based on the presence of cognitive impairment, reliable neuroimaging signs of CVD, and the exclusion of another cause of cognitive impairment.
The primary and secondary endpoints clearly demonstrated the significant superiority of tolpersione added to NSAID monotherapy over NSAID monotherapy. The safety assessment revealed no statistically significant differences between the two groups. Based on the results, tolpersione injection and per os formulations can be considered an effective and safe drugs in the combined therapy for patients with acute nonspecific back pain.
У пациентов с хронической ишемией мозга на фоне гипертонической болезни 2 степени 2 стадии выявлено существенное снижение содержания в мембране эритроцитов фосфолипидов в среднем на 30,1 %, эфиров холестерина – на 44,2 %, повышение уровня лизофосфатидилхолина, свободного холестерина, триацилглицеридов, свободных жирных кислот на 23,2 – 46,2 %, изменение соотношения фракций липидов, ответственных за структурообразование и стабилизацию мембраны эритроцитов. Установлено, что наибольшей эффективностью в коррекции нарушений липидного спектра мембраны эритроцитов обладает 10-дневное введение комбинации актовегина (200 мг внутривенно струйно) и церетона (1000 мг холина альфосцерата внутривенно капельно в 200,0 мл 0,9 % раствора хлорида натрия), наименьшей – церебролизина (2152 мг концентрата комплекса пептидов, полученных из головного мозга свиньи, внутривенно капельно в 100,0 мл 0,9 % раствора хлорида натрия) и мексидола (250 мг 2-этил-6-метил-3-гидроксипиридина сукцината внутривенно струйно). Применение эмоксипина (40 мг 3-окси-6-метил-2-этилпиридина внутримышечно) и пирацетама (1000 мг 2-оксо-1-пирролидин-ацетамида внутривенно струйно) дало промежуточные результаты.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.