Background & objectives:Renal tumours constitute about 7 per cent of all neoplasms in children. It is important to differentiate Wilms’ tumour (commonest tumour) from non-Wilms’ tumours. The aim of this study was to evaluate the immunoexpression and diagnostic role of Wilms’ tumour-1 protein (WT1) in paediatric renal tumours.Methods:A total of 53 cases of renal tumours in children (below 18 yr) who underwent total nephrectomy were included in this retrospective study. WT1 immunostaining was done using mouse monoclonal WT1 antibody (clone: 6F-H2).Results:Of the 53 cases, 38 (72%) were of Wilms’ tumour. Non-Wilms’ group (15) included six cases of mesoblastic nephroma (MN), two each of clear cell sarcoma (CCSK), renal cell carcinoma (RCC) and peripheral neuroectodermal tumour (PNET) and one each of angiomyolipoma (AML), rhabdomyosarcoma (RMS) and malignant rhabdoid tumour (MRT). Proportion of WT1 positivity in Wilms’ tumour was 100 per cent in contrast to 26.7 per cent in non-Wilms’ tumours (P<0.001). Epithelial and blastemal components of Wilms’ tumour showed moderate (2+) nuclear and cytoplasmic staining in 80 (24/30) and 75 per cent (24/32) cases, respectively. MN, PNET, CCSK and AML were negative for WT1. RMS, RCC and MRT showed cytoplasmic staining, strongest in RMS. No significant association was seen between WT1 expression and NWTSG (National Wilms’ Tumor Study Group) stage.Interpretation & conclusions:WT1 helps to differentiate Wilms’ tumour from other paediatric renal tumours. It may help in differentiating the two subgroups of Wilms’ tumour which have distinct molecular pathogenesis and biological behaviour, however, further prospective studies are required for validation of this hypothesis.
Objective: To create awareness about this rare tumour and the way it can mislead the clinician into believing it to be of an ovarian origin. Case report: A 50 years old postmenopausal female presented with a partly solid-partly cystic mass noted arising from the mesentery of sigmoid colon, obliterating the pouch of douglas and adhered to the posterior surface of uterus and right adnexa. The histopathological features were suggestive of Adenocarcinoma of Mullerian origin. Conclusion: Great caution and precision are needed to ascertain the origin and management of these tumours as they carry a bad prognosis.
Arsenicosis" is a known health hazard in certain areas of our country, contaminated drinking water being the chief source of intoxication. Common manifestations include typical pigmentation, keratosis with or without involvement of internal organs. The worst consequence is development of malignancies, typically squamous cell carcinoma and basal cell carcinoma among others. We report a case of a 50-year-old farmer from N-24 Paraganas (West Bengal, India) found to consume water with more than permissible arsenic level for almost 10 years, presenting with aforesaid cutaneous malignancies simultaneously. Chronic arsenic exposure is known to cause cutaneous malignancies in people. However, a simultaneous occurrence of both squamous and basal cell carcinomas in the same subject is rarely seen.
Xanthogranulomatous inflammation is a form of chronic inflammatory process with collection of foamy macrophages in sheets, often with presence of giant cell reaction. Here, we present a case of xanthogranulomatous osteomyelitis of tibia in a 43 years old patient, which is a rare pathological entity and possibly was reported first in 1984. The histopathological sections revealed dense collection of lympho-plasmacytic infiltrate in the marrow spaces with syncytial sheets of foamy macrophages admixed with numerous classical Touton giant cells.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.