This study was aimed to evaluate the possible analgesic properties of the ethanol extract of Hedyotis corymbosa L. (Rubiaceae) a locally available plant used in traditional medicine for the management of pain and other conditions. The dried powder of the whole plant was extracted with 95 % ethanol and was subjected first to various chemical tests to ascertain the main constituents contained in the extract. The result revealed the presence of alkaloids, flavonoids, tannins, glycosides in significant amounts. Then the extract was investigated for analgesic effect by using hot plate test, acetic acid induced writhing test and formalin test. The results showed that the ethanol extract of the plant at two different doses (250 and 500 mg/kg body weight) showed significant (p<0.05), dose-dependent analgesic effect which is mediated by both central and peripheral mechanism. The analgesic activity was compared with a standard drug, ketorolac used at a dose of 10 mg/kg body weight.
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