Flavonoid pada daun alpukat memiliki efek penghambatan angiotensin I terhadap perubahan angiotensin II menyebabkan efek vasodilatasi sehingga terjadi penurunan resistansi perifer yang menyebabkan tekanan darah menurun. Desain pra eksperimental Pretest-Posttest, Non-Equivalent Control Group Design. Populasinya lansia hipertensi 30 responden. Teknik sampel purposive sampling. Analisis data dengan Paired T-Test. Hasil penelitian menggunakan uji Paired T-Test diperoleh mean 0,167; standar deviasi 0,379; nilai t 2,408 (> t tabel = 1,699); dan nilai signifikansi p value 0,023 (<α = 0,05). Kesimpulan dari penelitian bahwa simplisia daun alpukat dapat menurunkan tekanan darah pada lansia hipertensi.
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