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The present study reports an alternative method of functionalizing the optical fiber Surface Plasmon Resonance (SPR) sensing probe with antibodies for label-free detection of bovine serum albumin (BSA) protein. In this novel approach, the gold coated fiber was first modified with Molybdenum disulfide (MoS 2 ) nanosheets followed by its bio-functionalization with Anti-BSA antibodies. The developed technique not only allowed the amplification of the SPR signals by synergic effects of MoS 2 and gold metallic thin film but also enabled a direct and chemical-free attachment of representative antibodies through hydrophobic interactions. The sensitivity of the MoS 2 modified sensing probe with detection limit of 0.29 µg/mL was improved as compared to the fiber optic SPR biosensor without MoS 2 overlayer (Detection limit  for BSA was 0.45 μg/mL). The developed biosensor has good specificity, and environmental stability. Accordingly, the proposed design of the MoS 2 based SPR optical biosensor can offer the development of a simplified optical device for the monitoring of various biomedical and environmental parameters.

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Strain induced due to impact was calculated from the Bragg wavelength shifts. Difference in the strain values for the two gratings is interpreted as impact energy absorbed by the mouthguard. The Bragg wavelength shifts (induced strain) for FBG bonded on the jaw model was much lower than the shift for FBG bonded on the mouthguard, indicating that most of the impact energy is absorbed by the mouthguard.