Background: Pityriasis capitis commonly known as dandruff is one of the most common and widely seen dermatological disease that affects majority of the world population. It is more than superficial flaking, as it leads to significant structural changes in the stratum corneum and inflammatory biomarkers. Various intrinsic and extrinsic factors, such as Malassezia yeast, host epidermal conditions, sebaceous secretion, and abnormal immune responses, are found to contribute to the pathogenesis. Regardless of wide research, detail understanding, and treatment modalities, it still remains to be a cause of concern due to its recurring nature. Aims: The objective of this study is to enhance the understanding of its wide causes, pathophysiology, current treatment, and future approach. Methods: The article also aims at evaluating various promising anti-dandruff agents that can be further researched to become the leads in anti-dandruff therapy. Results & Conclusion: The article summarizes the current knowledge on dandruff and present new facts and evidences in order to spread awareness, create potential for new herbal treatment options, and effectively control the most commercially exploited scalp disorder.
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The nutraceutical industry has three main segments including herbal/natural products, dietary supplements and
functional foods. The dietary supplements market is preliminarily driven by the paradigm shift toward preventive health
management practices, amid rising healthcare costs and increasing burden of lifestyle diseases. Rise in healthcare expenditure, increased usage of nutraceuticals product as a substitute to prescription and OTC drugs and augmented demand
for nutritional diet are the major factors driving the global nutraceuticals market. Many individual laws were devised to
govern its manufacturing and sale. However, increasing regulatory formalities from multiple agencies and laws, complicate
the development, testing and marketing of these substances and hamper the growth of the nutraceutical market. Globally,
the regulatory authorities are aware of changing needs of consumers and proactively protect consumers by amending existing laws to accommodate changes. Market entry requirements of nutraceuticals, functional foods and supplements vary
from country to country. The global regulatory guidelines aim at regulating various aspects of the nutraceutical and dietary
supplements market, focusing on its manufacture, testing, labeling, sale and registration to assure safety and quality of the
product. The major change that was introduced was the ban on marketing Nutraceuticals as medicinal products. This review
has been performed to provide a comprehensive understanding of the global regulatory requirements with critical analysis
of the Indian regulatory guidelines to explore the lacunae and suggest need of further amendments in the form of recommendations that can be incorporated into regulatory body guidelines to make it more competent for national & international
trade.
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