Highlights Cognitive impairment is a major comorbidity of temporal lobe epilepsy (TLE). Three discrete cognitive phenotypes of TLE are identified here. The phenotypes are linked to network, clinical, and socioeconomic characteristics. This taxonomy advances clinical and theoretical understanding of the cognitive complications of TLE.

Malignant brain tumors are aggressive tumors with a very poor prognosis. Survival is on average 12 to 18 months. Patients with malignant gliomas are subject to multiple medical problems that can significantly impact their overall survival and quality of life, including seizures, cerebral edema, venous thromboembolism, cognitive and psychiatric disorders, and side effects of chemotherapy, such as nausea, vomiting, myelosuppression, constipation, and diarrhea. This article examines the evidence for managing many of these issues to reduce symptoms and improve quality of life.

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