Neuroanatomical correlates of personality traits in temporal lobe epilepsy: Findings from the Epilepsy Connectome Project

Bonet, Charlene N. Rivera; Hermann, Bruce P.; Hwang, Gyujoon; Dabbs, Kevin; Nair, Veena A.; Forseth, Courtney; Mathis, Jedidiah; Allen, Linda; Almane, Dace; Arkush, Karina; Birn, Rasmus M.; Conant, Lisa L.; DeYoe, Edgar A.; Felton, Elizabeth A.; Humphries, Colin; Kraegel, Peter; Maganti, Rama; Nencka, Andrew S.; Nwoke, Onyekachi O.; Raghavan, Manoj; Rozman, Megan; Shah, Umang; Sosa, Veronica N.; Struck, Aaron F.; Tellapragada, Neelima; Ustine, Candida; Ward, B. Douglas; Prabhakaran, Vivek; Binder, Jeffrey R.; Meyerand, M. Elizabeth

doi:10.1016/j.yebeh.2019.07.025

Cited by 16 publications

(14 citation statements)

References 55 publications

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“…Specifically, the cognitive ToM is associated with greater activation in the dorsomedial prefrontal cortex, the dorsal anterior cingulate cortex, and the dorsal striatum ( 105 ), whereas the affective ToM is associated with greater activation in the ventromedial and orbitofrontal cortices, the ventral anterior cingulate cortex, the ventral striatum, and the amygdala ( 101 , 106 ). In multiple neuroanatomical reports, gray and white matter pathology in regions implicated in cognitive and affective ToM networks is observed in adult patients with TLE ( 67 , 107 – 111 ). Meta-regression analysis showed that more severe EF was associated with more severe ToM defects.…”

Section: Discussionmentioning

confidence: 99%

Theory of mind and facial emotion recognition in adults with temporal lobe epilepsy: A meta-analysis

Zhao

et al. 2022

Front. Psychiatry

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BackgroundMounting studies have investigated impairments in social cognitive domains (including theory of mind [ToM] and facial emotion recognition [FER] in adult patients with temporal lobe epilepsy (TLE). However, to date, inconsistent findings remain.MethodsA search of PubMed, Web of Science, and Embase databases was conducted until December 2021. Hedges g effect sizes were computed with a random-effects model. Meta-regressions were used to assess the potential confounding factors of between-study variability in effect sizes.ResultsThe meta-analysis included 41 studies, with a combined sample of 1,749 adult patients with TLE and 1,324 healthy controls (HCs). Relative to HCs, adult patients with TLE showed large impairments in ToM (g = −0.92) and cognitive ToM (g = −0.92), followed by medium impairments in affective ToM (g = −0.79) and FER (g = −0.77). Besides, no (statistically) significant differences were observed between the magnitude of social cognition impairment in adult with TLE who underwent and those who did not undergo epilepsy surgery. Meta-regressions exhibited that greater severity of executive functioning was associated with more severe ToM defects, and older age was associated with more severe FER defects.ConclusionsResults of this meta-analysis suggest that adult patients with TLE show differential impairments in the core aspects of social cognitive domains (including ToM and FER), which may help in planning individualized treatment with appropriate cognitive and behavioral interventions.

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Section: Discussionmentioning

confidence: 99%

Theory of mind and facial emotion recognition in adults with temporal lobe epilepsy: A meta-analysis

Zhao

et al. 2022

Front. Psychiatry

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“…The authors showed that neuroticism, a personality trait that is associated with depressive symptoms relates to atypical functional connectivity between mesiotemporal and frontal lobe regions, with connectivity alterations that were partially overlapping to those related to depression and anxiety symptoms ( Rivera Bonet et al, 2020 ). In an earlier study, the authors also reported associations between affective symptoms and reductions in gray matter volumes, again targeting both frontal and temporal neocortices, as well as mesiotemporal lobe structures such as the hippocampus and amygdala ( Rivera Bonet et al, 2019 ). Collectively, previous efforts to study socio-affective functioning in TLE highlight the role of fronto-limbic circuits, as well as the structural integrity of these regions, in mood-related symptoms.…”

Section: Temporal Lobe Epilepsymentioning

confidence: 93%

Multimodal connectome biomarkers of cognitive and affective dysfunction in the common epilepsies

Rodríguez‐Cruces

Royer

Larivière

et al. 2022

Network Neuroscience

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Epilepsy is one of the most common chronic neurological conditions, traditionally defined as a disorder of recurrent seizures. Cognitive and affective dysfunctions are increasingly recognized as core disease dimensions and can affect patient wellbeing sometimes more than the seizures themselves. Connectome-based approaches hold immense promise for revealing mechanisms that contribute to dysfunction, and to identify biomarkers. Our review discusses emerging multimodal neuroimaging and connectomics studies that highlight network substrates of cognitive/affective dysfunction in the common epilepsies. We first overview work in drug-resistant epilepsy syndromes i.e., temporal lobe epilepsy related to mesiotemporal sclerosis (TLE) and extratemporal epilepsy (ETE) related to malformations of cortical development. While these are traditionally conceptualized as ‘focal’ epilepsies, many patients present with broad structural and functional anomalies. Moreover, the extent of distributed changes contributes to difficulties in multiple cognitive domains as well as affective-behavioral challenges. We will also review work in idiopathic generalized epilepsy (IGE), a class of generalized epilepsy syndromes that involve subcortico-cortical circuits. Overall, neuroimaging and network neuroscience studies point to both shared and syndrome specific connectome signatures of dysfunction across TLE, ETE, and IGE. Lastly, we point to current gaps in the literature and formulate recommendations for future research.

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“…Patients participating in the ECP all had a diagnosis of TLE based on clinical, radiographic, and EEG criteria as described in previous papers. 17,18 Data acquisition T1w and T2w structural images were obtained using 3T GE (General Electric) 750 MRI scanners at UW and MCW. T1w scans used a magnetization prepared gradient echo (MPRAGE) sequence (TR = 604 msec, TE = 2.516 msec, TI = 1060.0 msec, flip angle = 8°, FOV = 25.6 cm, 0.8 mm isotropic), and T2w scans used a 3D fast spin-echo (CUBE) sequence (TR = 2500 msec, TE = 94.398 msec, flip angle = 90°, FOV = 25.6 cm, 0.8 mm isotropic).…”

Section: Methods Participantsmentioning

confidence: 99%

“…Selection criteria included an estimated IQ of at least 70, fluency in English, and age from 18 to 60 years (ECP) or 55 to 90 years (ADCP). Patients participating in the ECP all had a diagnosis of TLE based on clinical, radiographic, and EEG criteria as described in previous papers 17,18 …”

Section: Methodsmentioning

confidence: 99%

T1−/T2‐weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy

Denis,

Dabbs,

Nair

et al. 2023

Ann Clin Transl Neurol

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Short‐range functional connectivity in the limbic network is increased in patients with temporal lobe epilepsy (TLE), and recent studies have shown that cortical myelin content correlates with fMRI connectivity. We thus hypothesized that myelin may increase progressively in the epileptic network. We compared T1w/T2w gray matter myelin maps between TLE patients and age‐matched controls and assessed relationships between myelin and aging. While both TLE patients and healthy controls exhibited increased T1w/T2w intensity with age, we found no evidence for significant group‐level aberrations in overall myelin content or myelin changes through time in TLE.

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Neuroanatomical correlates of personality traits in temporal lobe epilepsy: Findings from the Epilepsy Connectome Project

Cited by 16 publications

References 55 publications

Theory of mind and facial emotion recognition in adults with temporal lobe epilepsy: A meta-analysis

Theory of mind and facial emotion recognition in adults with temporal lobe epilepsy: A meta-analysis

Multimodal connectome biomarkers of cognitive and affective dysfunction in the common epilepsies

T1−/T2‐weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy

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