This study was carried out to evaluate the effect of ammonia toxicity on the growth and hematology of Clarias gariepinus. The mean weight gain of fish 1.52 ± 0.3 g was investigated under laboratory conditions at static bioassay for 96 h and 14 days, respectively. Five treatments of 96 h median lethal concentration LC50 were used, namely, T0 (0.00 g·l−1), T1 (0.40 g·l−1), T2 (0.60 g·l−1), T3 (0.80 g·l−1) and T4 (1.00 g·l−1), and each of these treatment concentrations was replicated three times for both toxicity exposures. The results clearly revealed that 96 h median lethal concentration (LC50) at treatments T4 (4.00), T3 (3.00), T2 (2.00) and T0 (0.00) g·l−1 gave an average mean value of 3.02 ± 0.02 g·l−1 with upper and lower limits of 6.28 and 1.42 g·l−1, respectively. The overall percentage mortality showed more than 71% of fish mortality at T4. Values for the 14 -day sub-acute exposures to ammonia concentrations of T4 (1.00), T3 (0.80), T2 (0.60) and control (0.00) g·l−1 were also obtained. Growth indices indicated significant decreases (P<0.05) in the total feed intake (TFI), specific growth rate (SGR), mean weight gain and food conversion ratio (FCR) compared with the control.
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