The dual delivery platforms used in bone tissue engineering provide supplementary bioactive compounds that include distinct medicines and growth factors thereby aiding enhanced bone regeneration. The delivery of these compounds can be adjusted for a short or prolonged time based on the requirement by altering various parameters of the carrier platform. The platforms thus used are fabricated to mimic the niche of the bone microenvironment, either in the form of porous 3D structures, microspheres, or films. Thus, this review article focuses on the concept of dual drug delivery platform and its importance, classification of various platforms for dual drug delivery specific to bone tissue engineering, and finally highlights the foresight into the future direction of these techniques for better clinical applications.

Introduction Hearing is one of the traditional five senses that is also the fastest sense. Inadequate hearing acuity especially during early age has serious effects on the development of a child’s personality. According to World Health Organization, around 466 million people worldwide have disabling hearing loss and of these ~34 million are children. Hearing loss in children may occur due to several reasons, but ~60% of childhood hearing loss occurs from preventable causes. An early detection of these conditions plays an important role in reduction in magnitude of this problem. Aims and Objectives The motive of this study is to estimate the prevalence of hearing impairment among school-going children in Ghaziabad on the basis of otological findings and tuning fork tests. Materials and Methods A random sample of 500 school-going children between the ages of 6 to 14 years was selected from children attending ENT OPD in Santosh Hospital, Ghaziabad, over a period of 8 months from July 2019 till February 2020. Results and Conclusion Prevalence rate encountered in this study was 13%, with unilateral hearing loss being more common than bilateral. The commonest cause was found to be cerumen. A higher prevalence was found in children from semiurban and low socioeconomic background. Since the commonest cause is preventable and readily correctable by proper management, early detection can reduce the burden of this disability.

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