Synthesis of mesoporous silica nanoparticlesCTAB (0.5g) 2.0M NaOH (1.75ml) and deionised water (120g) *
AbstractMesoporous silica nanoparticles MCM -41 were synthesized with two dimensional hexagonal p6mm symmetry, KLJK VSHFL¿F VXUIDFH DUHDa P 2 J QDUURZ SRUH VL]H DQG DQ DYHUDJH SDUWLFOH VL]H RI QP 7KH SURGXFHG nanoparticles were used to encapsulate carbamazepine through a supercritical carbon dioxide process combined with various organic solvents. Supercritical processing was found to provide increased drug encapsulation. The loaded MCM -41 nanoparticles were analyzed using X-ray diffraction and differential scanning calorimetry (DSC) to investigate the crystalline state of the encapsulated carbamazepine and it was found to be dependent on the nature of the organic solvent. Carbamazepine showed increased dissolution rates under sink conditions. Viability studies of Caco -2 cells demonstrated negligible cytotoxicity for the MCM-41 nanoparticles.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.