Synthesis of mesoporous silica nanoparticlesCTAB (0.5g) 2.0M NaOH (1.75ml) and deionised water (120g) *
AbstractMesoporous silica nanoparticles MCM -41 were synthesized with two dimensional hexagonal p6mm symmetry, KLJK VSHFL¿F VXUIDFH DUHDa P 2 J QDUURZ SRUH VL]H DQG DQ DYHUDJH SDUWLFOH VL]H RI QP 7KH SURGXFHG nanoparticles were used to encapsulate carbamazepine through a supercritical carbon dioxide process combined with various organic solvents. Supercritical processing was found to provide increased drug encapsulation. The loaded MCM -41 nanoparticles were analyzed using X-ray diffraction and differential scanning calorimetry (DSC) to investigate the crystalline state of the encapsulated carbamazepine and it was found to be dependent on the nature of the organic solvent. Carbamazepine showed increased dissolution rates under sink conditions. Viability studies of Caco -2 cells demonstrated negligible cytotoxicity for the MCM-41 nanoparticles.
In this method,Leucaena leucocephalaseed pods (LLSP) have been used for removal of Cu(II) ions from aqueous solution. Batch adsorption experiments were conducted to study the effect of process parameters like pH, contact time initial Cu(II) ions concentration and adsorbent dose. The maximum adsorption of Cu(II) ions onLeucaena leucocephalaseed pods was 94.17% at pH 5. The amount of metal adsorbed per unit weight of adsorbent increases with time and reach equilibrium after 30 minutes of shaking time for the different initial metal concentrations. The Freundlich and Langmuir isotherm equations were applied for the equilibrium adsorption data and the various isotherm parameters were evaluated. The obtained plots were linear as evident fromR2values close to unity. The data agreed very well with the pseudo second-order kinetic model.
Tizanidine HCl is a drug with poor water solubility, oral bioavailability and high first pass metabolism. The present study aims at developing a nano formulation by nanoprecipitation method to improve the oral bioavailability. Five formulations (F1-F5) with different polymer ratios were prepare and optimized on the basis of entrapment efficiency. In vitro release kinetics of formulations shows extended release of drug over a period of 128 h. Optimized formulation F3 shows better stability and oral bioavailability 3.6 times more than pure drug.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.