N1-Phenyl Substituted 4-Quinolones of Tuberculostatic Activity. -The N1-phenyl-6-fluoro-7-piperazinyl-4-quinolone 3-carboxylates (I) and the diazoniumtetrafluoroborate of sparfloxacin (II) are tested for their ability to inhibit the growth of Mycobacterium strains. -(HOLZGRABE, U.; STEIN-ERT, M.; Pharmazie 56 (2001) 11, 850-851; Inst. Pharm. Lebensmittelchem.,
The dimethylaminomethylcycloalkanones (I) react with the N‐methylbenzylamines (II) to yield the benzylated amino ketones (III) which are oxidatively cyclized with Ce(SO4)2, forming the spiro‐fused tetrahydroisoquinolines (IV).
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